Estimating and comparing the distribution of onset of disease from prevalence case-control data.
Estimating and comparing the distribution of onset of disease from prevalence case-control data.
复制标题
根据患病率病例对照数据估计和比较疾病发作的分布。
DOI：
10.1111/j.1541-0420.2005.00407.x
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Bagiella,Emilia
中科院分区：
文献类型：
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作者：
Bagiella,Emilia
从流行病例对照数据确定的年龄确定了特定年龄的疾病几率。当从病例中获得发病年龄时，在疾病发生的情况下，发病年龄的条件分布是可确定的。通过引入乘法截距将两种信息结合起来，可以确定发病年龄的边际分布。在这里，该方法通过乘截距模型的泛化扩展到双样本设置。探讨了该方法的有效性，并提出了一种基于分布函数估计之间的积分差的检验统计量。讨论了似然的正则化方法。该方法是通过应用数据的结肠直肠息肉从个人接受结肠镜检查的病例对照研究中获得。
Age at ascertainment from prevalence case–control data identifies the age-specific odds of disease. When age at onset is available from the cases, the conditional distribution of age at onset, given that disease occurs, is identifiable. Combining both kinds of information by introducing a multiplicative intercept allows identification of the marginal distribution of age at onset. Here, the approach is extended to the two-sample setting through a generalization of the multiplicative intercept model. The efficiency of the approach is explored and a test statistic based on the integrated difference between distribution function estimates is proposed. An approach to regularization of the likelihood is discussed. The methods are illustrated through an application to data on colorectal polyps obtained from a case–control study of individuals undergoing colonoscopy.