Antimalarial and antitubercular C-glycosylated benz[α]anthraquinones from the marine-derived Streptomyces sp BCC45596
Antimalarial and antitubercular C-glycosylated benz[α]anthraquinones from the marine-derived Streptomyces sp BCC45596
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DOI：
10.1016/j.phytol.2012.06.015
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发表时间：
2012-09-01
影响因子：
1.7
通讯作者：
Pittayakhajonwut, Pattama
中科院分区：
文献类型：
--
作者：
Supong, Khomsan;Thawai, Chitti;Pittayakhajonwut, Pattama
已从海洋链霉菌中分离出三种天然新的C-糖基化苯并蒽醌衍生物：乌达霉素E(1)、乌达霉素G(2)、脱羟基水霉素(3)。 BCC45596。乌达霉素 E (4)（1-3 的可能生物合成前体）也在菌株重新培养后得到鉴定。这些化合物 (1-4) 表现出有效的抗疟原虫 K1 菌株，IC50 值在 0.0534-2.93 μg/mL 范围内，抗结核分枝杆菌，最小抑制浓度 (MIC) 在 3.13-12.50 μg/mL 范围内。还评估了针对 KB、MCF-7、NCI-H187 和 Vero 细胞的细胞毒性。 (C) 2012 年欧洲植物化学协会。由 Elsevier B.V 出版。保留所有权利。
Three naturally new C-glycosylated benz[alpha]anthraquinone derivatives, urdamycinone E (1), urdamycinone G (2), dehydroxyaquayamycin (3) have been isolated from the marine Streptomycetes sp. BCC45596. Urdamycin E (4), the possible biosynthetic precursor of 1-3, has also been identified after a recultivation of the strain. These compounds (1-4) exhibited potent anti-Plasmodium palcifarum K1 strain with IC50 values in a range of 0.0534-2.93 mu g/mL and anti-Mycobacterium tuberculosis with minimum inhibition concentrations (MICs) in a range of 3.13-12.50 mu g/mL. Cytotoxicity against KB, MCF-7, NCI-H187, and Vero cells was also evaluated. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.