Disentangling PK-PD in neonates
Disentangling PK-PD in neonates
复制标题
解开新生儿的 PK-PD
DOI：
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
B. Anderson
中科院分区：
文献类型：
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作者：
B. Anderson
Allegaert等人对该论文的评论
新生儿镇痛是一个人道的考虑，扑热息痛提供了一个合理的替代轻度至中度疼痛。扑热息痛（扑热息痛（对乙酰氨基酚）的一种静脉给药前药）在早产儿中静脉给药后的研究很少受到关注。我们可以预期丙扑热息痛在临床上具有优势，因为可以快速达到血浆目标浓度，并且由于吸收动力学和相对生物利用度而导致的变异性降低。此外，静脉注射药物提供了更清晰的药代动力学研究，可以进一步加深我们对早产儿和足月儿中扑热息痛药代动力学的了解。1 -5 Allegaert等人研究了扑热息痛在早产儿中的使用，值得祝贺。新生儿药代动力学研究充满了陷阱。
出生后（出生后年龄）清除率通常迅速增加，无论出生时的胎龄如何。这项研究围绕这一...
A commentary on the paper by Allegaert et al
Neonatal analgesia is a humane consideration, and paracetamol offers a reasonable alternative for mild to moderate pain. The investigation of propacetamol, an intravenous prodrug of paracetamol (acetaminophen), in premature neonates after intravenous administration has received scant attention. We might expect propacetamol to offer advantages clinically because a plasma target concentration can be rapidly attained and variability due to absorption kinetics and relative bioavailability is reduced. In addition, an intravenous drug offers a cleaner pharmacokinetic study that can further our knowledge of paracetamol pharmacokinetics in premature and term neonates.1–5 Allegaert et al are to be congratulated for investigating propacetamol use in premature neonates. Neonatal pharmacokinetic studies are fraught with pitfalls.
Clearance often increases rapidly after birth (postnatal age) no matter what the gestational age at birth. This study gets around this …