APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos
APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos
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DOI：
10.1073/pnas.022523499
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发表时间：
2002-01-22
影响因子：
11.1
通讯作者：
Priess, JR
中科院分区：
文献类型：
--
作者：
Goutte, C;Tsunozaki, M;Priess, JR
秀丽隐杆线虫胚胎中的早期胚胎细胞通过与果蝇和脊椎动物中的Notch信号通路密切相关的信号通路相互作用。该途径的组分包括配体、受体、早老素蛋白和一种与人类Nicastrin蛋白相关的新型蛋白APH-2。在这里，我们确定的aph-1基因作为一个新的组成部分的Notch途径在秀丽隐杆线虫。据预测，aph-1编码一种新的、高度保守的多通道膜蛋白。我们发现，aph-1和早老素基因有着相似的功能，因为它们都是APH-2/Nicastrin的适当细胞表面定位所必需的。
Early embryonic cells in Caenorhabditis elegans embryos interact through a signaling pathway closely related to the Notch signaling pathway in Drosophila and vertebrates. Components of this pathway include a ligand, receptor, the presenilin proteins, and a novel protein, APH-2, that is related to the Nicastrin protein in humans. Here we identify the aph-1 gene as a new component of the Notch pathway in Caenorhabditis elegans. aph-1 is predicted to encode a novel, highly conserved multipass membrane protein. We show that aph-1 and the presenilin genes share a similar function in that they are both required for proper cell-surface localization of APH-2/Nicastrin.