Zinc Absorption by Adults Is Similar from Intrinsically Labeled Zinc-Biofortified Rice and from Rice Fortified with Labeled Zinc Sulfate
Zinc Absorption by Adults Is Similar from Intrinsically Labeled Zinc-Biofortified Rice and from Rice Fortified with Labeled Zinc Sulfate
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DOI：
10.3945/jn.115.213421
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发表时间：
2016-01-01
影响因子：
4.2
通讯作者：
Hurrell, Richard F.
中科院分区：
文献类型：
--
作者：
Brnic, Marica;Wegmueller, Rita;Hurrell, Richard F.
背景资料：主食作物的生物强化是防治锌缺乏症的一项有希望的战略，对于大米和不作为面粉食用、因此不适合收获后强化的作物特别有意义。由于植酸（PA）和其他膳食成分会降低锌的吸收，因此在确定生物强化作物的功效之前，测量其对锌的吸收非常重要。目的：在本研究中，我们比较了锌生物强化大米对锌的吸收，（ZnSO_4）-Zn-70营养强化的水稻品种与对照水稻品种相比，70在使用点达到相同的总锌含量1.1毫克/餐。两种米粉的PA：Zn摩尔比均为12。方法：用双同位素示踪比值法测定16名健康成人[18-45岁; BM I]的锌吸收分数（FAZ）。（单位：kg/m（2））19-251人，在交叉设计中以随机顺序每4周吃2顿饭。结果：来自生物强化大米的FAZ（平均值+/- SD：25.1 +/- 8.7%）与使用点强化大米没有显著差异（平均SD：20.8 +/- 7.1%）（P = 0.08）。这些结果表明，在生物强化大米中积累的天然锌很容易从大米基质中释放出来，并且其被成年人吸收受到PA和其他物质的影响。食品成分中的无机锌化合物，以类似的方式添加到大米在使用点。此外，稻米生物强化可能与收获后锌强化一样好，是防治缺锌的一种干预策略。该试验在临床试验中注册。gov为NCT 01633450。
Background: Biofortification of staple food crops is a promising strategy to combat zinc deficiency, and it is of particular interest for rice and crops that are not consumed as flours and therefore not suitable for postharvest fortification. Because zinc absorption is decreased by phytic acid (PA) and perhaps other dietary components, it is important to measure the absorption of zinc from a biofortified crop before determining its efficacy.Objective: In this study, we compared the zinc absorption from zinc-biofortified rice (hydroponically enriched with Zn-70) with that from a control rice of the same variety fortified with (ZnSO4)-Zn-70 at point of use to reach the same total zinc content of 1.1 mg/meal. Both rice meals had a PA:Zn molar ratio of 12.Methods: Fractional absorption of zinc (FAZ) was measured with the use of the double-isotope tracer ratio method in 16 apparently healthy adults [18-45 y old; BM I (in kg/m(2)) 19-251 who consumed 2 single meals at 4-wk intervals in random order in a crossover design.Results: The FAZ from the biofortified rice (mean +/- SD: 25.1 +/- 8.7%) did not differ significantly from that of the point-of-use fortified rice (mean SD: 20.8 +/- 7.1%) (P = 0.08).Conclusions: These results suggest that the native zinc accumulated in the biofortified rice was readily released from the rice matrix and that its absorption by adults was influenced by PA and other food components in a similar way to the inorganic zinc compound added to the rice at point of use. Moreover, rice biofortification is likely to be as good as postharvest zinc fortification as an intervention strategy to combat zinc deficiency. This trial was registered at clinicaltrials. gov as NCT01633450.