Dual Origin of the Epithelium of the Mammalian Middle Ear
Dual Origin of the Epithelium of the Mammalian Middle Ear
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DOI：
10.1126/science.1232862
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发表时间：
2013-03-22
期刊：
影响因子：
56.9
通讯作者：
Tucker, Abigail S.
中科院分区：
文献类型：
--
作者：
Thompson, Hannah;Tucker, Abigail S.
哺乳动物中耳充满空气的腔和小听骨将声音传导到耳蜗。利用转基因小鼠，我们发现哺乳动物中耳是通过神经嵴肿块空化而发育的。这些细胞在离开神经管后经历上皮细胞到间质细胞的转化，经历间质细胞到上皮细胞的转化，形成与内胚层来源的听管相连的内膜。来自内胚层细胞的上皮，包围着耳管和鼓膜，发育纤毛，而神经嵴来源的上皮不发育纤毛。因此，清除中耳致病性感染的关键纤毛是根据发育衍生分布的。鸟类和爬行动物的空化过程明显不同，表明这种双上皮可能是哺乳动物所特有的。
The air-filled cavity and ossicles of the mammalian middle ear conduct sound to the cochlea. Using transgenic mice, we show that the mammalian middle ear develops through cavitation of a neural crest mass. These cells, which previously underwent an epithelial-to-mesenchymal transformation upon leaving the neural tube, undergo a mesenchymal-to-epithelial transformation to form a lining continuous with the endodermally derived auditory tube. The epithelium derived from endodermal cells, which surrounds the auditory tube and eardrum, develops cilia, whereas the neural crest-derived epithelium does not. Thus, the cilia critical to clearing pathogenic infections from the middle ear are distributed according to developmental derivations. A different process of cavitation appears evident in birds and reptiles, indicating that this dual epithelium may be unique to mammals.