Emerging roles for HMGA2 in colorectal cancer.
Emerging roles for HMGA2 in colorectal cancer.
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HMGA2 在结直肠癌中的新作用
DOI：
10.1016/j.tranon.2020.100894
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发表时间：
2021-01
影响因子：
5
通讯作者：
Wu J
中科院分区：
文献类型：
--
作者：
Wang X;Wang J;Wu J
HMGA 2（High Mobility Group AT-hook 2）通过调节靶基因的转录而促进结直肠癌（CRC）的发展。它参与细胞过程的几乎所有方面，包括细胞转化、增殖、凋亡、衰老、转移、上皮-间质转化（EMT）、DNA修复和干细胞自我更新。在过去的几十年中，已经在广泛的癌症中鉴定了一组下游靶标和结合伴侣。HMGA 2在MDM 2/p53、IL 11/STAT 3和Wnt/β-catenin信号通路中起关键作用的研究结果促使我们总结HMGA 2在CRC中的功能和分子基础的最新进展。本文就HMGA 2在结直肠癌致癌网络中的作用作一综述。我们回顾其异常表达，探讨潜在的机制，讨论其促肿瘤发生的作用，并强调有前途的小分子抑制剂的基础上，针对HMGA 2在这里。然而，HMGA 2在CRC进展中的理解仍然是难以捉摸的，因此我们也在此综述中讨论了未来的前景。总的来说，这篇综述为HMGA 2的致癌特性提供了新的见解，这在CRC的诊断和治疗中具有潜在的意义。HMGA 2通过调节靶基因的转录促进结直肠癌（CRC）的发展。循环无细胞HMGA 2 mRNA已被确定为CRC的潜在筛选标志物。HMGA 2在结直肠癌中可能是MDM 2/p53、IL 11/STAT 3和Wnt/β-catenin信号通路网络中的关键因子。许多药物和siRNA通过靶向HMGA 2作为潜在的治疗方法用于治疗CRC。破译HMGA 2介导的机制有助于构思有效的治疗策略，并在CRC中开发新的抑制剂。
HMGA2 (High Mobility Group AT-hook 2) has been reported to promote colorectal cancer (CRC) development by regulating the transcription of target genes. It participates in nearly all aspects of cellular processes, including cell transformation, proliferation, apoptosis, senescence, metastasis, epithelial-to-mesenchymal transition (EMT), DNA repair and stem cell self-renewal. In the past decades, a group of downstream targets and binding partners have been identified in a wide range of cancers. Our findings of HMGA2 as a key factor in the MDM2/p53, IL11/STAT3 and Wnt/β-catenin signaling pathways prompt us to summarize current advances in the functional and molecular basis of HMGA2 in CRC. In this review, we address the roles of HMGA2 in the oncogenic networks of CRC based on recent advances. We review its aberrant expression, explore underlying mechanisms, discuss its pro-tumorigenic effects, and highlight promising small-molecule inhibitors based on targeting HMGA2 here. However, the understanding of HMGA2 in CRC progression is still elusive, thus we also discuss the future perspectives in this review. Collectively, this review provides novel insights into the oncogenic properties of HMGA2, which has potential implications in the diagnosis and treatment of CRC. HMGA2 promotes colorectal cancer (CRC) development by regulating the transcriptions of target genes. Circulating cell-free HMGA2 mRNA has been identified as a potential screening marker in CRC. HMGA2 appears to be a key factor in the networks of MDM2/p53, IL11/STAT3 and Wnt/β-catenin signaling pathways in CRC. Many agents and siRNAs serve as potential therapeutic approaches by targeting HMGA2 for the treatment of CRC. Deciphering HMGA2-mediated machinery helps to conceive effective therapy strategies and develop novel inhibitors in CRC.
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DOI：
10.1038/nrc.2017.99
发表时间：
2018-01
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Anastasiadou E;Jacob LS;Slack FJ
通讯作者：
Slack FJ
影响因子：
11.2
作者：
Frankenberger C;Rabe D;Bainer R;Sankarasharma D;Chada K;Krausz T;Gilad Y;Becker L;Rosner MR
通讯作者：
Rosner MR
影响因子：
12.4
作者：
Chang HY;Ye SP;Pan SL;Kuo TT;Liu BC;Chen YL;Huang TC
通讯作者：
Huang TC
影响因子：
4.6
作者：
Chang KP;Lin SJ;Liu SC;Yi JS;Chien KY;Chi LM;Kao HK;Liang Y;Lin YT;Chang YS;Yu JS
通讯作者：
Yu JS
影响因子：
11.2
作者：
Gao D;Vahdat LT;Wong S;Chang JC;Mittal V
通讯作者：
Mittal V