Cytotoxic and apoptosis-inducing ent-kaurane-type diterpenoids from the Japanese liverwort Jungermannia truncata NEES
Cytotoxic and apoptosis-inducing ent-kaurane-type diterpenoids from the Japanese liverwort Jungermannia truncata NEES
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DOI：
10.1248/cpb.50.808
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发表时间：
2002-06-01
影响因子：
1.7
通讯作者：
Asakawa, Y
中科院分区：
文献类型：
--
作者：
Nagashima, F;Kondoh, M;Asakawa, Y
从日本地钱中分离得到5个新的龙脑烷型二萜化合物和1个新的龙胆烷型倍半萜化合物，以及12个已知的龙脑烷型二萜类化合物。新化合物的结构经二维核磁共振实验和化学反应确证。其中一些化合物对人白血病细胞株具有细胞毒作用，并能诱导细胞凋亡。
Five new ent-kaurane-type diterpenoids and a new gymnomitrane (=barbatane)-type sesquiterpenoid have been isolated from the Japanese liverwort Jungermannia truncata NEES, together with twelve previously known ent-kaurane-type diterpenoids. The structures of the new compounds were elucidated by two-dimensional (2D) NMR experiments and chemical reaction. Some of the isolated compounds showed cytotoxicity against human leukemia cell lines and induced apoptosis.