The lack of effect of chronic metabolic acidosis on 25-OH-vitamin D metabolism and serum parathyroid hormone in humans.
The lack of effect of chronic metabolic acidosis on 25-OH-vitamin D metabolism and serum parathyroid hormone in humans.
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慢性代谢性酸中毒对人体25-OH-维生素D代谢和血清甲状旁腺激素缺乏影响。
DOI：
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发表时间：
1976
影响因子：
5.8
通讯作者：
Jacob Lemann
中科院分区：
文献类型：
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作者：
Hugo P. Weber;Richard W. Gray;Jesus H. Dominguez;Jacob Lemann
我们评估了营业额的血浆25-OH-维生素D池，酸，矿物质平衡的配对平衡研究6名正常受试者在正常酸碱条件下，在稳定的慢性代谢性酸中毒引起的氯化铵。如前所述，观察到高钙尿症导致的正酸平衡和负钙平衡。在对照期间，血浆25-OH-D库周转率平均为6.1+/-0.4 nmol/d，在酸中毒期间没有变化（6.5 +/-0.5 nmol/d），在酸中毒期间观察到的Ca、PO 4或Mg的净肠道吸收也没有任何显著增加，这是维生素D作用的生理表达。在另外3名受试者中，在7个对照日和24天稳定NH 4Cl酸中毒期间重复测量血清iPTH未显示变化。我们解释的数据，以支持这一假设，无论是甲状旁腺素或维生素D及其代谢产物介导的净骨吸收，必须伴随慢性代谢性酸中毒的增加。
We evaluated the turnover of the plasma 25-OH-vitamin D pool, acid, and mineral balances in paired balance studies of 6 normal subjects during normal acid base conditions and during stable chronic metabolic acidosis induced by NH4Cl. Positive acid balances and negative Ca balances due to hypercalciuria were observed as previously reported. Plasma 25-OH-D pool turnover averaged 6.1+/-0.4 nmol/day during control and did not change during acidosis (6.5 +/- 0.5 nmol/day) nor were any significant increments in net intestinal absorption of Ca, PO4, or Mg, the physiological expression of vitamin D action, observed during acidosis. In 3 other subjects, repetitive measurements of serum iPTH during 7 control days and 24 days of stable NH4Cl acidosis showed no changes. We interpret the data to support the hypothesis that neither PTH nor vitamin D and its metabolites mediates the increase in net bone resorption that must accompany chronic metabolic acidosis.