Lipid transport proteins in malaria, from plasmodium parasites to their hosts.
Lipid transport proteins in malaria, from plasmodium parasites to their hosts.
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DOI：
10.1016/j.bbalip.2021.159047
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
M. Ressurreição;C. van Ooij
中科院分区：
文献类型：
--
作者：
M. Ressurreição;C. van Ooij
来自疟原虫属的真核单细胞病原体是疟疾的病原体，疟疾是一种在包括人类在内的广泛脊椎动物物种中持续存在的疾病。在其动态的生命周期中，在不同宿主中的存活取决于寄生虫建立合适环境的能力。为了实现这一目标，利用特定的宿主过程来支持最佳生长，包括对受感染的宿主细胞进行广泛的修饰。这些改变包括由寄生虫诱导的新膜结构的形成。因此，为了维持精细调节和动态的脂质环境，脂质向不同细胞位点的组织和分布可能需要专门的脂质转移蛋白（LTP）。事实上，已经鉴定了几种寄生虫和宿主衍生的LTP，并显示其在特定阶段是必不可少的。在这里，我们描述了LTP在寄生虫发育和适应宿主中的作用，包括最新研究如何从可用于研究疟原虫的改进的遗传、脂质组学和成像工具包中受益。最后，提供了一个预测的PlasmodiumLTP列表，以鼓励在这一领域的研究。
Eukaryotic unicellular pathogens from the genusPlasmodiumare the etiological agents of malaria, a disease that persists over a wide range of vertebrate species, including humans. During its dynamic lifecycle, survival in the different hosts depends on the parasite's ability to establish a suitable environmental milieu. To achieve this, specific host processes are exploited to support optimal growth, including extensive modifications to the infected host cell. These modifications include the formation of novel membranous structures, which are induced by the parasite. Consequently, to maintain a finely tuned and dynamic lipid environment, the organisation and distribution of lipids to different cell sites likely requires specialised lipid transfer proteins (LTPs). Indeed, several parasite and host-derived LTPs have been identified and shown to be essential at specific stages. Here we describe the roles of LTPs in parasite development and adaptation to its host including how the latest studies are profiting from the improved genetic, lipidomic and imaging toolkits available to studyPlasmodiumparasites. Lastly, a list of predictedPlasmodiumLTPs is provided to encourage research in this field.