The Impact of Pruritus on Quality of Life The Skin Equivalent of Pain
The Impact of Pruritus on Quality of Life The Skin Equivalent of Pain
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DOI：
10.1001/archdermatol.2011.178
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发表时间：
2011-10-01
影响因子：
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通讯作者：
Chen, Suephy C.
中科院分区：
文献类型：
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作者：
Kini, Seema P.;DeLong, Laura K.;Chen, Suephy C.
目的：使用直接得出的健康效用评分来比较慢性瘙痒和慢性疼痛对生活质量 (QoL) 的影响。设计：横断面研究。设置：就诊于佐治亚州亚特兰大埃默里皮肤科诊所、埃默里脊柱中心和埃默里疼痛管理中心的患者的方便样本。参与者：经历慢性疼痛或瘙痒 6 周或更长时间的成年男性和女性（年龄 >= 18 岁）。结果测量：将慢性瘙痒患者的平均效用评分与慢性疼痛患者的平均效用评分进行比较。进行回归分析以确定主要预测变量症状类型对主要结果变量均值效用评分（代表对生活质量影响的指标）的影响。 结果：该研究包括 73 名慢性瘙痒患者和 138 名慢性疼痛患者。瘙痒患者的平均效用 (SD) 为 0.87 (0.27)，而疼痛患者的平均效用为 0.77 (0.31) (P < .01)。在控制症状严重程度、持续时间和人口因素后，只有症状严重程度 (0.03 [P < .05]) 和单一婚姻状况 (-0.12 [P =. 02])，而不是症状类型 (P =. 43)，仍然是平均症状效用评分的显着预测因素。 结论：慢性瘙痒对生活质量有重大影响，其影响可能与疼痛相当。症状的严重程度和支持网络的使用是决定患者受症状影响程度的主要因素。除了开发新疗法之外，解决支持网络问题可能会改善瘙痒患者的生活质量。
Objective: To compare the impact of chronic pruritus and chronic pain on quality of life (QoL) using directly elicited health utility scores.Design: Cross-sectional study.Setting: Convenience sample of patients attending the Emory Dermatology Clinic, Emory Spine Center, and Emory Center for Pain Management, Atlanta, Georgia.Participants: Adult men and women (aged >= 18 years) experiencing chronic pain or pruritus for 6 weeks or more.Main Outcome Measures: The mean utility score of patients with chronic pruritus was compared with that of patients with chronic pain. A regression analysis was performed to determine the impact of the primary predictor variable-symptom type-on the primary outcome variable-mean utility score (a metric representing the impact on QoL).Results: The study included 73 patients with chronic pruritus and 138 patients with chronic pain. The mean (SD) utility among patients with pruritus was 0.87 (0.27) compared with 0.77 (0.31) for patients with pain (P < .01). After symptom severity, duration, and demographic factors were controlled for, only symptom severity (0.03 [P < .05]) and single marital status (-0.12 [P =. 02]), but not symptom type (P =. 43), remained significant predictors of the mean symptom utility score.Conclusions: Chronic pruritus has a substantial impact on QoL, one that may be comparable to that of pain. The severity of symptoms and the use of support networks are the main factors that determine the degree to which patients are affected by their symptoms. Addressing support networks in addition to developing new therapies may improve the QoL of itchy patients.