Association between breast cancer risk and the wild-type allele of human ABC transporter ABCC11.
Association between breast cancer risk and the wild-type allele of human ABC transporter ABCC11.
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发表时间：
2010-12
影响因子：
2
通讯作者：
I. Ota;A. Sakurai;Y. Toyoda;S. Morita;Takeshi Sasaki;T. Chishima;M. Yamakado;Y. Kawai;T. Ishidao;A. Lezhava;K. Yoshiura;S. Togo;Y. Hayashizaki;T. Ishikawa;T. Ishikawa;I. Endo;H. Shimada
中科院分区：
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作者：
I. Ota;A. Sakurai;Y. Toyoda;S. Morita;Takeshi Sasaki;T. Chishima;M. Yamakado;Y. Kawai;T. Ishidao;A. Lezhava;K. Yoshiura;S. Togo;Y. Hayashizaki;T. Ishikawa;T. Ishikawa;I. Endo;H. Shimada
乳腺癌的国际死亡率和发病率与人类耳垢的湿型有关。最近发现，耳垢类型由ABCC 11中的单核苷酸多态性（SNP）538 G>A（Gly 180 Arg）决定。G等位基因决定了耳垢的湿润类型，这是一种显性表型的孟德尔性状。本研究探讨了乳腺癌的频率与ABCC 11的G等位基因频率之间的关系。患者和方法使用来自浸润性乳腺癌患者（n = 270）和对照志愿者（n = 273）的血液样本，使用SmartRisk方法对ABCC 11中的538 G>A SNP进行基因分型。结果乳腺癌患者G等位基因频率高于健康对照组。基因型（G/G+G/A）发生乳腺癌的比值比估计为1.63（p值= 0.026），表明ABCC 11中的G等位基因与乳腺癌风险相关。结论：本研究表明，日本妇女有湿耳垢比干耳垢有较高的相对风险发展为乳腺癌。决定这些表型的ABCC 11 SNPs应该进一步研究，以深入了解乳腺癌发生和发展的机制。
BACKGROUND International mortality and frequency rates for breast cancer have been associated with the wet type of human earwax. It was recently found that earwax type is determined by a single nucleotide polymorphism (SNP), 538G>A (Gly180Arg), in ABCC11. The G allele determines the wet type of earwax as a Mendelian trait with a dominant phenotype. The present study examined the association between the frequency rate of breast cancer and the frequency of the G allele of ABCC11. PATIENTS AND METHODS Using blood samples from patients with invasive breast cancer (n = 270) and control volunteers (n = 273), the 538G>A SNP in ABCC11 was genotyped using the SmartAmp method. RESULTS The frequency of the G allele in breast cancer patients was higher than that in healthy controls. The odds ratio for the genotypes (G/G+G/A) to develop breast cancer was estimated to be 1.63 (p-value = 0.026), suggesting that the G allele in ABCC11 is associated with breast cancer risk. CONCLUSION This study showed that Japanese women with wet earwax have a higher relative risk of developing breast cancer than those with dry earwax. The ABCC11 SNPs that determine these phenotypes should be further investigated in order to obtain insights into the mechanisms by which breast cancer develops and progresses.