Chronic hepatitis C liver microenvironment: role of the Th17/Treg interplay related to fibrogenesis.
Chronic hepatitis C liver microenvironment: role of the Th17/Treg interplay related to fibrogenesis.
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DOI：
10.1038/s41598-017-13777-3
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发表时间：
2017-10-16
影响因子：
4.6
通讯作者：
Preciado MV
中科院分区：
文献类型：
--
作者：
Rios DA;Valva P;Casciato PC;Frias S;Soledad Caldirola M;Gaillard MI;Bezrodnik L;Bandi J;Galdame O;Ameigeiras B;Krasniansky D;Brodersen C;Mullen E;Matteo EN;Preciado MV
不同淋巴细胞群在慢性丙型肝炎（CHC）患者肝脏微环境中的作用仍存在争议。由于Th 17和Treg具有相反的功能，它们的平衡可能会影响疾病的进展。目的是探讨成人CHC患者肝脏微环境及其外周血对应物。肝脏中以CD 4+淋巴细胞为主，Foxp 3+频率高，但IL-17 A+频率低。IL-17 A+淋巴细胞和IL-17 A +/Foxp 3+比率显示与晚期纤维化相关（分别为p = 0.0130; p = 0.0236），而Foxp 3+淋巴细胞和IL-10表达水平与纤维化严重程度负相关（分别为p = 0.0381，p = 0.0398）。TGF-β/IL-6比值与IL-17 A +/Foxp 3+比值（p = 0.0036，r = 0.5944）和IL-17 A+淋巴细胞（p = 0.0093; r = 0.5203）相关。TNF-α和TGF-β与肝炎严重程度相关（p = 0.0409，p = 0.0321）。外周血淋巴细胞频率与肝损害无关。有功能不同的免疫细胞群积极参与肝损伤，但肝脏细胞因子环境实际上驱动发病机制。除了低IL-17 A+淋巴细胞频率之外，肝内Foxp 3+淋巴细胞占优势，描绘了向Foxp 3+淋巴细胞倾斜的IL-17 A +/Foxp 3+平衡。然而，IL-17 A+淋巴细胞与晚期纤维化的关联表明它们在发病机制中的作用。因此，Th 17和Treg之间的相互作用调节肝纤维化。
The role of the different lymphocyte populations in liver microenvironment of chronic hepatitis C (CHC) patients is still matter of debate. Since Th17 and Treg have opposite functions, their balance could affect disease progression. The aim was to explore liver microenvironment and its peripheral blood counterpart in adult CHC patients. CD4+ lymphocytes were predominant in the liver, with high Foxp3+ but low IL-17A+ frequency. IL-17A+ lymphocytes and IL-17A+/Foxp3+ ratio displayed association with advanced fibrosis (p = 0.0130; p = 0.0236, respectively), while Foxp3+ lymphocytes and IL-10 expression level inversely correlated with fibrosis severity (p = 0.0381, p = 0.0398, respectively). TGF-β/IL-6 ratio correlated with IL-17A+/Foxp3+ ratio (p = 0.0036, r = 0.5944) and with IL-17A+ lymphocytes (p = 0.0093; r = 0.5203). TNF-α and TGF-β were associated with hepatitis severity (p = 0.0409, p = 0.0321). Peripheral blood lymphocyte frequency was not associated with liver damage. There are functionally different immune cell populations actively involved in liver damage, but the liver cytokine milieu actually drives the pathogenesis. The intrahepatic Foxp3+ lymphocytes predominance beside the low IL-17A+ lymphocytes frequency, delineate a skewed IL-17A+/Foxp3+ balance towards Foxp3+ lymphocytes. However, the IL-17A+ lymphocytes association with advanced fibrosis denotes their role in the pathogenesis. Therefore, the interplay between Th17 and Treg conditions liver fibrogenesis.
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影响因子：
32.4
作者：
Hu W;Troutman TD;Edukulla R;Pasare C
通讯作者：
Pasare C
影响因子：
8
作者：
Schon, Hans-Theo;Weiskirchen, Ralf
通讯作者：
Weiskirchen, Ralf
影响因子：
25.7
作者：
Langhans, Bettina;Kraemer, Benjamin;Spengler, Ulrich
通讯作者：
Spengler, Ulrich
DOI：
10.1073/pnas.94.20.10663
发表时间：
1997-09-30
影响因子：
11.1
作者：
Shi, ZD;Wakil, AE;Rockey, DC
通讯作者：
Rockey, DC
影响因子：
4.1
作者：
Arce-Sillas A;Álvarez-Luquín DD;Tamaya-Domínguez B;Gomez-Fuentes S;Trejo-García A;Melo-Salas M;Cárdenas G;Rodríguez-Ramírez J;Adalid-Peralta L
通讯作者：
Adalid-Peralta L