CBP-mediated post-translational N-glycosylation of BRCA2.
CBP-mediated post-translational N-glycosylation of BRCA2.
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DOI：
10.3892/ijo_00000351
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发表时间：
2009-08
影响因子：
5.2
通讯作者：
H. Siddique;V. Rao;E. Reddy
中科院分区：
文献类型：
--
作者：
H. Siddique;V. Rao;E. Reddy
CREB binding protein (CBP) is a transcriptional cofactor with intrinsic histone acetyl transferase activity (HAT). We have observed that CBP interacts with BRCA2 and mediates post-translational glycosylation of BRCA2. The binding of CBP to the amino-terminal region of BRCA2 is necessary for the glycosylation at residue 272 of BRCA2. Digestion with peptide N-glycosidase F indicates that the glycosylation of BRCA2 is N-linked. It is possible that this novel CBP-mediated post-translational N-glycosylation activity alters the conformation of CBP-interacting proteins, leading to regulation of gene expression, cell growth and differentiation.
