Effects of vitamin D-fortified low fat yogurt on glycemic status, anthropometric indexes, inflammation, and bone turnover in diabetic postmenopausal women: A randomised controlled clinical trial
Effects of vitamin D-fortified low fat yogurt on glycemic status, anthropometric indexes, inflammation, and bone turnover in diabetic postmenopausal women: A randomised controlled clinical trial
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DOI：
10.1016/j.clnu.2015.02.014
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发表时间：
2016-02-01
影响因子：
6.3
通讯作者：
Askari, Gholamreza
中科院分区：
文献类型：
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作者：
Jafari, Tina;Faghihimani, Elham;Askari, Gholamreza
背景和目的：血清 25-羟基维生素 D (25(OH)D) 水平低在 2 型糖尿病患者中很常见，并且由于其衰老和生理状况而导致多种并发症，尤其是绝经后妇女。本研究旨在评估强化维生素 D 的低脂酸奶对患有糖尿病的绝经后女性的血糖状况、人体测量指数、炎症和骨转换的影响。 方法：在一项随机、安慰剂对照、双盲平行组临床试验中，59 名患有 2 型糖尿病的绝经后女性接受了强化酸奶（2000 财年） IU 维生素 D（100 克/天）或原味酸奶 (PY)，持续 12 周。在基线和12周后评估血糖标志物、人体测量指标、炎症和骨转换标志物。结果：干预后，FY组（相对于PY组）观察到：血清25（OH）D显着升高，PTH降低（PY中稳定值）；血清空腹胰岛素、HOMA-IR、HOMA-B、QUICK! 显着改善，而血清空腹血糖和 HbA(1c) 无变化（PY 中所有指标均显着恶化）； WC、WHR、FM 显着改善，体重和 BMI 没有变化（PY 值稳定）；网膜蛋白显着增加（PY 中稳定）和 sNTX 减少（PY 中显着增加）。与PY组相比，FY组的血糖标志物（HbA(1c)除外）、网膜蛋白和骨转换标志物的最终值显着改善。关于FY组血清25(OH)D的最终值，将受试者分为不足类别和充足类别。血糖状况在不足类别中比充足类别中改善得更显着；结论：每日饮用 2000 IU 维生素 D 强化酸奶，连续 12 周改善了绝经后 2 型糖尿病女性的血糖指标（HbA(1c) 除外）、人体测量指标、炎症和骨转换指标。 (C) 2015 Elsevier Ltd 和欧洲临床营养与代谢学会。版权所有。
Background & aims: Low levels of serum 25-hydroxy vitamin D (25(OH)D) are common in type 2 diabetic patients and cause several complications particularly, in postmenopausal women due to their senile and physiological conditions. This study aimed to assess the effects of vitamin D-fortified low fat yogurt on glycemic status, anthropometric indexes, inflammation, and bone turnover in diabetic postmenopausal women.Methods: In a randomized, placebo-controlled, double-blind parallel-group clinical trial, 59 postmenopausal women with type 2 diabetes received fortified yogurt (FY; 2000 IU vitamin D in 100 g/day) or plain yogurt (PY) for 12 weeks. Glycemic markers, anthropometric indexes, inflammatory, and bone turnover markers were assessed at baseline and after 12 weeks.Results: After intervention, in FY group (vs PY group), were observed: significant increase in serum 25(OH)D and decrease of PTH (stable values in PY); significant improvement in serum fasting insulin, HOMA-IR, HOMA-B, QUICK!, and no changes in serum fasting glucose and HbA(1c), (significant worsening of all indexes in PY); significant improvement in WC, WHR, FM, and no change in weight and BMI (stable values in PY); significant increase of omentin (stable in PY) and decrease of sNTX (significant increase in PY). Final values of glycemic markers (except HbA(1c)), omentin, and bone turnover markers significantly improved in FY group compared to PY group. Regarding final values of serum 25(OH)D in FY group, subjects were classified in insufficient and sufficient categories. Glycemic status improved more significantly in the insufficient rather than sufficient category; whereas the other parameters had more amelioration in the sufficient category.Conclusions: Daily consumption of 2000 IU vitamin D-fortified yogurt for 12 weeks improved glycemic markers (except HbA(1c)), anthropometric indexes, inflammation, and bone turnover markers in postmenopausal women with type 2 diabetes. (C) 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.