GreenCircRNA: a database for plant circRNAs that act as miRNA decoys
GreenCircRNA: a database for plant circRNAs that act as miRNA decoys
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GreenCircRNA：充当 miRNA 诱饵的植物 circRNA 数据库
DOI：
10.1093/database/baaa039
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发表时间：
2020-06-08
影响因子：
5.8
通讯作者：
Li, Guanglin
中科院分区：
文献类型：
--
作者：
Zhang, Jingjing;Hao, Zhiqiang;Li, Guanglin
环状rna （Circular rna, circRNAs）是一种内源性非编码rna，形成共价闭合的连续环，分布广泛，在一系列发育过程中发挥重要作用。在植物中，越来越多的研究发现环状rna可以调节植物代谢，参与植物对生物或非生物胁迫的反应。作为miRNA诱饵是circrna发挥其功能的关键途径。因此，我们开发了greencircrna -一个作为miRNA诱饵的植物环状rna数据库，致力于为详细探索植物环状rna及其潜在诱饵功能提供一个基于植物的平台。该数据库包括来自69种植物的超过21万个环状rna；该数据库中circrna的主要数据来源为NCBI、EMBL-EBI和Phytozome。为了研究circRNAs作为竞争性内源rna的功能，研究人员预测了来自38种植物的circRNAs作为miRNA诱饵的可能性。此外，我们还提供了数据库中circRNA的基本信息，包括它们的位置、宿主基因和相对表达水平，以及全长序列、宿主基因GO （gene Ontology）编号和circRNA可视化。GreenCircRNA是第一个用于预测环状rna的数据库，环状rna作为miRNA的诱饵，包含最多的植物物种。数据库地址：http://greencirc.cn
Abstract Circular RNAs (circRNAs) are endogenous non-coding RNAs that form a covalently closed continuous loop, are widely distributed and play important roles in a series of developmental processes. In plants, an increasing number of studies have found that circRNAs can regulate plant metabolism and are involved in plant responses to biotic or abiotic stress. Acting as miRNA decoys is a critical way for circRNAs to perform their functions. Therefore, we developed GreenCircRNA—a database for plant circRNAs acting as miRNA decoys that is dedicated to providing a plant-based platform for detailed exploration of plant circRNAs and their potential decoy functions. This database includes over 210 000 circRNAs from 69 species of plants; the main data sources of circRNAs in this database are NCBI, EMBL-EBI and Phytozome. To investigate the function of circRNAs as competitive endogenous RNAs, the possibility of circRNAs from 38 plants to act as miRNA decoys was predicted. Moreover, we provide basic information for the circRNAs in the database, including their locations, host genes and relative expression levels, as well as full-length sequences, host gene GO (Gene Ontology) numbers and circRNA visualization. GreenCircRNA is the first database for the prediction of circRNAs that act as miRNA decoys and contains the largest number of plant species. Database URL: http://greencirc.cn