Design and synthesis of sialyl Lewis x mimics as E-selectin inhibitors

Design and synthesis of sialyl Lewis x mimics as E-selectin inhibitors
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DOI:
10.1016/s0960-894x(00)00623-5
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发表时间:
2001-01-22
影响因子:
2.7
通讯作者:
Crommie, D
Crommie, D
中科院分区:
医学4区
文献类型:
--
作者:
Kaila, N;Thomas, BE;Crommie, D

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The design and synthesis of novel beta -C-mannosides that inhibit the binding of sialyl Lewis x to E-selectin are described. Compounds that contained a phenyl substituent at the C-6 position were found to have increased potency. (C) 2001 Elsevier Science Ltd. All rights reserved.