Cardiac regeneration.
Cardiac regeneration.
复制标题
心脏再生。
DOI：
10.1016/b978-0-12-387786-4.00010-5
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发表时间：
2012
影响因子：
--
通讯作者：
Poss, Kenneth D.
中科院分区：
文献类型：
--
作者：
Choi, Wen-Yee;Poss, Kenneth D.
心脏是由心肌细胞和其他细胞类型组成的泵，其正常功能对生活质量至关重要。成年哺乳动物无法在损伤后触发心肌再生，这是一个具有重大临床影响的缺陷。主要的研究工作正试图通过细胞疗法的进步或激活仅存在于生命早期的内源性再生机制来改变这一点。与哺乳动物相比，像斑马鱼这样的低等脊椎动物表现出令人印象深刻的心脏再生能力。本文综述了心脏再生领域的最新进展，重点是内源性再生能力及其潜在的操纵。
The heart is a pump that is comprised of cardiac myocytes and other cell types and whose proper function is critical to quality of life. The ability to trigger regeneration of heart muscle following injury eludes adult mammals, a deficiency of great clinical impact. Major research efforts are attempting to change this through advances in cell therapy or activating endogenous regenerative mechanisms that exist only early in life. By contrast with mammals, lower vertebrates like zebrafish demonstrate an impressive natural capacity for cardiac regeneration throughout life. This review will cover recent progress in the field of heart regeneration with a focus on endogenous regenerative capacity and its potential manipulation.