Formal Synthesis of Teadenols via Palladium-Catalyzed 6- endo Cyclization of an Epoxyphenol
Formal Synthesis of Teadenols via Palladium-Catalyzed 6- endo Cyclization of an Epoxyphenol
复制标题
通过钯催化环氧酚的 6- 端环化正式合成 Teadenol
作者：
Kitamura M.; Suetake;H.; Hoshino;K.; Higashijima;Y.; Kisanuki;M.; Yuasa;R.; Yamaguchi;Y.; Shimazu;T.; Koga;N.; Hamada;H.; Miyori;N.; Shimooka;H.; Okauchi;T.
茶烯醇A和B的正式合成是通过具有乙烯基环氧部分的苯酚的关键Pd催化的6-内环化来实现的。虽然5-exocyclations和6-endocyclations竞争在环氧化物的环化与亲核部分在5-位，6-endocyclations实现通过使用钯催化剂。
Formal syntheses of teadenols A and B are achieved via a key Pd-catalyzed 6-endocyclization of a phenol possessing a vinyl epoxide moiety. Although 5-exoand 6-endocyclizations compete during cyclizations of epoxides with a nucleophilic moiety at the 5-position, 6-endocyclization is realized by using a palladium catalyst.