TIRAP in the Mechanism of Inflammation.
TIRAP in the Mechanism of Inflammation.
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DOI：
10.3389/fimmu.2021.697588
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发表时间：
2021
影响因子：
7.3
通讯作者：
Baig MS
中科院分区：
文献类型：
--
作者：
Rajpoot S;Wary KK;Ibbott R;Liu D;Saqib U;Thurston TLM;Baig MS
Toll-IL-1受体(TIR)结构域适配子蛋白(TIRAP)是一种重要的细胞内信号分子，调节多种免疫应答。它作为接头分子的功能与Toll样受体(TLR)介导的先天性免疫信号有关已被广泛研究。自从2001年TIRAP被发现以来，最初的研究主要集中在它作为一个接头蛋白的作用，将髓系分化因子88(MyD88)与TLRs偶联，激活依赖MyD88的TLRs信号。随后的研究描述了TIRAP通过与非TLR信号媒介的相互作用而作为信号事件的转导者的作用。事实上，TIRAP与一系列细胞内信号媒介相互作用的能力表明，它在各种免疫反应中发挥着核心作用。因此，继续研究阐明各种TIRAP-蛋白质相互作用的分子基础以及它们如何影响信号幅度，应该会为炎症性疾病的机制提供关键信息。这篇综述综述了TIRAP对激活受体的募集，并讨论了与急慢性炎症性疾病之前的信号有关的相互作用的机制。此外，我们强调了TIRAP-TIR结构域包含几个细胞内炎症信号分子的结合位点的重要性。总而言之，我们讨论了TIR结构域在TIRAP中作为参与蛋白质相互作用的关键界面的重要性，因此可以作为治疗靶点来抑制急性和慢性炎症条件的程度。
The Toll-interleukin-1 Receptor (TIR) domain-containing adaptor protein (TIRAP) represents a key intracellular signalling molecule regulating diverse immune responses. Its capacity to function as an adaptor molecule has been widely investigated in relation to Toll-like Receptor (TLR)-mediated innate immune signalling. Since the discovery of TIRAP in 2001, initial studies were mainly focused on its role as an adaptor protein that couples Myeloid differentiation factor 88 (MyD88) with TLRs, to activate MyD88-dependent TLRs signalling. Subsequent studies delineated TIRAP’s role as a transducer of signalling events through its interaction with non-TLR signalling mediators. Indeed, the ability of TIRAP to interact with an array of intracellular signalling mediators suggests its central role in various immune responses. Therefore, continued studies that elucidate the molecular basis of various TIRAP-protein interactions and how they affect the signalling magnitude, should provide key information on the inflammatory disease mechanisms. This review summarizes the TIRAP recruitment to activated receptors and discusses the mechanism of interactions in relation to the signalling that precede acute and chronic inflammatory diseases. Furthermore, we highlighted the significance of TIRAP-TIR domain containing binding sites for several intracellular inflammatory signalling molecules. Collectively, we discuss the importance of the TIR domain in TIRAP as a key interface involved in protein interactions which could hence serve as a therapeutic target to dampen the extent of acute and chronic inflammatory conditions.
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DOI：
10.1084/jem.20140654
发表时间：
2015-09-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Baig MS;Zaichick SV;Mao M;de Abreu AL;Bakhshi FR;Hart PC;Saqib U;Deng J;Chatterjee S;Block ML;Vogel SM;Malik AB;Consolaro ME;Christman JW;Minshall RD;Gantner BN;Bonini MG
通讯作者：
Bonini MG
DOI：
10.1016/b978-0-12-805417-8.00018-4
发表时间：
2018-01-01
期刊：
IMMUNITY AND INFLAMMATION IN HEALTH AND DISEASE: EMERGING ROLES OF NUTRACEUTICALS AND FUNCTIONAL FOODS IN IMMUNE SUPPORT
影响因子：
--
作者：
Biswas, Chhanda
通讯作者：
Biswas, Chhanda
影响因子：
7.3
作者：
Belhaouane I;Hoffmann E;Chamaillard M;Brodin P;Machelart A
通讯作者：
Machelart A
影响因子：
30.5
作者：
Chuang, TH;Ulevitch, RJ
通讯作者：
Ulevitch, RJ
影响因子：
4.8
作者：
Chow, JC;Young, DW;Gusovsky, F
通讯作者：
Gusovsky, F