Association between Resting-State Coactivation in the Parieto-Frontal Network and Intelligence during Late Childhood and Adolescence
Association between Resting-State Coactivation in the Parieto-Frontal Network and Intelligence during Late Childhood and Adolescence
复制标题
顶额叶网络静息态共激活与儿童晚期和青春期智力之间的关联
DOI：
10.3174/ajnr.a3850
复制
发表时间：
2014-06-01
影响因子：
3.5
通讯作者：
Tian, L.
中科院分区：
文献类型：
--
作者：
Li, C.;Tian, L.
背景和目的：许多研究将成人智商与双侧顶额网络的结构和功能联系起来，而在儿童早期，智商与顶额网络功能的关系相对较弱。由于人类智力和大脑功能在成年后都经历了漫长的发展过程，本研究的目的是更好地了解顶额网络与智商的关系。材料和方法：我们分别对84名儿童和50名青少年的静息态fMRI数据进行了独立成分分析，然后将全量表智商与各组的双侧顶额网络的空间图进行了相关分析。研究结果：在儿童中，在右侧顶额网络中的右侧角回和额下回中检测到显著的正相关，而在左侧顶额网络中未观察到显著的相关。在青少年中，左额下回在左顶额网络中检测到显著的正相关，而额极在两个顶额网络中的相关性仅是边缘显著的。结论：目前的研究结果不仅支持顶叶-额叶网络对智力的关键作用，而且表明，智商和右半球的顶叶-额叶网络之间的关系在儿童晚期已经建立，左半球的关系也在青春期建立。
BACKGROUND AND PURPOSE: A number of studies have associated the adult intelligence quotient with the structure and function of the bilateral parieto-frontal networks, whereas the relationship between intelligence quotient and parieto-frontal network function has been found to be relatively weak in early childhood. Because both human intelligence and brain function undergo protracted development into adulthood, the purpose of the present study was to provide a better understanding of the development of the parieto-frontal network–intelligence quotient relationship. MATERIALS AND METHODS: We performed independent component analysis of resting-state fMRI data of 84 children and 50 adolescents separately and then correlated full-scale intelligence quotient with the spatial maps of the bilateral parieto-frontal networks of each group. RESULTS: In children, significant positive spatial-map versus intelligence quotient correlations were detected in the right angular gyrus and inferior frontal gyrus in the right parieto-frontal network, and no significant correlation was observed in the left parieto-frontal network. In adolescents, significant positive correlation was detected in the left inferior frontal gyrus in the left parieto-frontal network, and the correlations in the frontal pole in the 2 parieto-frontal networks were only marginally significant. CONCLUSIONS: The present findings not only support the critical role of the parieto-frontal networks for intelligence but indicate that the relationship between intelligence quotient and the parieto-frontal network in the right hemisphere has been well established in late childhood, and that the relationship in the left hemisphere was also established in adolescence.