A sea of biosynthesis: marine natural products meet the molecular age.
A sea of biosynthesis: marine natural products meet the molecular age.
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DOI：
10.1039/c0np90032j
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发表时间：
2011-02
影响因子：
11.9
通讯作者：
Moore BS
中科院分区：
文献类型：
--
作者：
Lane AL;Moore BS
2000 年至 2010 年中期标志着人们对海洋天然产物生物合成认识的转变时期。在这十年中，该领域从一个主要以化学方法为主的理解生物合成途径的领域发展到了一个融合了现代分子生物学和生物信息学全部力量的领域。化学和生物方法的融合在理解海洋天然产物生物合成的遗传和酶学基础方面取得了巨大进展。海洋微生物，尤其是放线菌和蓝细菌，取得的进展尤其显着。在这十年间，第一个完整的海洋微生物天然产物生物合成基因簇序列以及第一个富含次生代谢物的海洋微生物的完整基因组序列被发布。这十年在认识海洋无脊椎动物微生物共生体在天然产物生物合成中的关键作用方面也取得了巨大进展。在此期间，遗传和酶学知识的应用导致了新型“非天然”天然产物的基因工程，以及通过基因组挖掘发现新型天然产物的机会。当前的综述重点介绍了 2000 年至 2010 年 6 月期间选定的开创性研究，这些研究说明了在遗传、酶和小分子天然产物水平上对海洋天然产物生物合成的理解取得的突破。共引用参考文献154篇。
The years 2000 through mid-2010 marked a transformational period in understanding of the biosynthesis of marine natural products. During this decade the field emerged from one largely dominated by chemical approaches to understanding biosynthetic pathways to one incorporating the full force of modern molecular biology and bioinformatics. Fusion of chemical and biological approaches yielded great advances in understanding the genetic and enzymatic basis for marine natural product biosynthesis. Progress was particularly pronounced for marine microbes, especially actinomycetes and cyanobacteria. During this single decade, both the first complete marine microbial natural product biosynthetic gene cluster sequence was released as well as the first entire genome sequence for a secondary metabolite-rich marine microbe. The decade also saw tremendous progress in recognizing the key role of marine microbial symbionts of invertebrates in natural product biosynthesis. Application of genetic and enzymatic knowledge led to genetic engineering of novel “unnatural” natural products during this time, as well as opportunities for discovery of novel natural products through genome mining. The current review highlights selected seminal studies from 2000 through to June 2010 that illustrate breakthroughs in understanding of marine natural product biosynthesis at the genetic, enzymatic, and small-molecule natural product levels. A total of 154 references are cited.
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影响因子：
--
作者：
Buchholz TJ;Rath CM;Lopanik NB;Gardner NP;Håkansson K;Sherman DH
通讯作者：
Sherman DH
影响因子：
7.3
作者：
DEGNAN, BM;HAWKINS, CJ;WATTERS, DJ
通讯作者：
WATTERS, DJ
影响因子：
18.3
作者：
Blasiak, Leah C.;Drennan, Catherine L.
通讯作者：
Drennan, Catherine L.
DOI：
10.1073/pnas.0610503104
发表时间：
2007-01-30
影响因子：
11.1
作者：
Butcher, Rebecca A.;Schroeder, Frank C.;Clardy, Jon
通讯作者：
Clardy, Jon
影响因子：
2.8
作者：
Allen, EE;Bartlett, DH
通讯作者：
Bartlett, DH