MicroRNA-Let-7f reduces the vasculogenic mimicry of human glioma cells by regulating periostin-dependent migration
MicroRNA-Let-7f reduces the vasculogenic mimicry of human glioma cells by regulating periostin-dependent migration
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MicroRNA-Let-7f 通过调节骨膜素依赖性迁移减少人胶质瘤细胞的血管生成拟态
DOI：
10.3892/or.2016.4548
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发表时间：
2016-03-01
期刊：
影响因子：
4.2
通讯作者：
Li, Gang
中科院分区：
文献类型：
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作者：
Xue, Hao;Gao, Xiao;Li, Gang
本研究首次检测了microRNA-let-7f(miR-let-7f)抑制人脑胶质瘤细胞血管生成拟态(Vm)的作用。Vm阳性的胶质瘤患者术后生存时间明显低于无Vm的患者。因此，有理由推测miR-let-7f通过抑制胶质瘤的Vm而发挥有效的肿瘤抑制作用。然而，涉及的分子机制仍然不清楚。我们的初步研究表明，miR-let-7f通过干扰Periostin(POSTN)诱导的胶质瘤细胞迁移而抑制Vm。我们的结果清楚地表明，通过miR-let-7f的过表达来抑制POSTN的亲迁移功能显著减少了VM的形成。我们的研究结果提示，miR-let-7f可能通过抑制Vm而成为胶质瘤抗血管生成治疗的潜在补充治疗靶点。
The present study was the first to examine the effect of microRNA-Let-7f (miR-Let-7f) inhibiting vasculogenic mimicry (VM) of human glioma cells. The postoperative survival time was significantly poor in VM-positive glioma patients compared with those without VM. Thus, it is reasonable to postulate that miR-Let-7f functions as a potent tumor suppressor by inhibiting glioma VM. However, the molecular mechanisms involved remain poorly clarified. Our preliminary studies revealed that miR-Let-7f suppressed VM by disturbing periostin (POSTN)-induced migration of glioma cells. Our results clearly demonstrated that inhibiting the pro-migratory function of POSTN by the overexpression of miR-Let-7f significantly reduced the formation of VM. Our findings suggest that miR-Let-7f may serve as a potential complementary therapeutic target in the anti-angiogenesis treatment of gliomas via suppressing VM.