Motor Function Test Reliability During the NeuroNEXT Spinal Muscular Atrophy Infant Biomarker Study.
Motor Function Test Reliability During the NeuroNEXT Spinal Muscular Atrophy Infant Biomarker Study.
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DOI：
10.3233/jnd-180327
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发表时间：
2018-01-01
影响因子：
3.3
通讯作者：
Kolb, Stephen J
中科院分区：
文献类型：
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作者：
Krosschell, Kristin J;Bosch, Michael;Kolb, Stephen J
背景：NeuroNEXT SMA婴儿生物标记物研究是一项为期两年的纵向多中心研究，对患有SMA 1型的婴儿和健康婴儿进行研究，提供了一个独特的机会来评估三种通常用于评估SMA 1型婴儿的婴儿运动功能测试(MFT)的多部位评分员可靠性。目的：确定未来MFT评分员培训的效果以及评分员经验对婴儿运动表现筛查项目测试(TIMPSI)评分员间和评分员内可靠性的影响，费城儿童医院婴儿神经肌肉疾病测试(CHOP-INTENT)和艾伯塔省婴儿运动量表(AIMS)。方法：使用一套新的运动功能测试(MFT)视频进行培训，以优化MFT的准确管理和研究持续时间的可靠性。使用组内相关系数(ICC)评估TIMPSI评分的评分者间和评分者内的可靠性，以及CHOP意图和AIMS的评分者间评分的可靠性。使用ICC检验评分员经验对信度的影响。使用皮尔逊相关系数检验与专家共识得分的一致性。结果：所有MFT的评分者间信度为良好到优秀。在研究持续时间内，主要MFT-TIMPSI的评定者内部可靠性非常好。培训后，与“专家”共识的一致性在预定范围内(≥85%)。评估人员使用SMA和MFTs的经验不影响可靠性。结论：所有三项研究MFTs的评估人员得分都是可靠的，重复给药的得分是重复性的。评估者的经验对可靠性没有影响。
BACKGROUND: The NeuroNEXT SMA Infant Biomarker Study, a two year, longitudinal, multi-center study of infants with SMA type 1 and healthy infants, presented a unique opportunity to assess multi-site rater reliability on three infant motor function tests (MFTs) commonly used to assess infants with SMA type 1.OBJECTIVE: To determine the effect of prospective MFT rater training and the effect of rater experience on inter-rater and intra-rater reliability for the Test of Infant Motor Performance Screening Items (TIMPSI), the Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP-INTEND) and the Alberta Infant Motor Scale (AIMS).METHODS: Training was conducted utilizing a novel set of motor function test (MFT) videos to optimize accurate MFT administration and reliability for the study duration. Inter- and intra-rater reliability of scoring for the TIMPSI and inter-rater reliability of scoring for the CHOP INTEND and the AIMS was assessed using intraclass correlation coefficients (ICC). Effect of rater experience on reliability was examined using ICC. Agreement with 'expert' consensus scores was examined using Pearson's correlation coefficients.RESULTS: Inter-rater reliability on all MFTs was good to excellent. Intra-rater reliability for the primary MFT, the TIMPSI, was excellent for the study duration. Agreement with 'expert' consensus was within predetermined limits (≥85%) after training. Evaluator experience with SMA and MFTs did not affect reliability.CONCLUSIONS: Reliability of scores across evaluators was demonstrated for all three study MFTs and scores were reproducible on repeated administration. Evaluator experience had no effect on reliability.