Association of Vascular Properties With the Brain White Matter Hyperintensity in Middle-Aged Population.
Association of Vascular Properties With the Brain White Matter Hyperintensity in Middle-Aged Population.
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DOI：
10.1161/jaha.121.024606
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发表时间：
2022-06-07
影响因子：
5.4
通讯作者：
Nyquist, Paul A.
中科院分区：
文献类型：
--
作者：
Hannawi, Yousef;Vaidya, Dhananjay;Yanek, Lisa R.;Johansen, Michelle C.;Kral, Brian G.;Becker, Lewis C.;Becker, Diane M.;Nyquist, Paul A.
关键词：
由于脑室周围白色物质的血管结构和与体循环的关系不同，其对体循环血流动力学的变化比深部白色物质更敏感。我们假设，脑室周围白色高信号（PVWMH）体积比深部白色高信号（DWMH）体积与反映动脉僵硬度和心血管重构（体循环指标）的血管特性（VP）之间存在更大的相关性。共研究了426名参与动脉粥样硬化风险遗传研究的参与者（年龄：59.0±6.1岁; 57.5%为女性; 39.7%为黑人），这些参与者年龄≥50岁，并进行了脑磁共振成像。VP包括脉压、高血压运动反应、舒张期肱动脉内径、舒张期颈总动脉内径、颈总动脉扩张系数和左心室功能。使用多水平线性模型确定VP与PVWMH和DWMH作为同一个体内的多个测量的相对关联。我们还确定了年龄是否改变了VP与PVWMH和DWMH相关性的差异。我们的研究结果表明，在同一受试者中，PVWMH体积比DWMH体积与脉压（P=0.002）、运动高血压反应（P=0.04）、舒张期肱动脉直径（P=0.012）和舒张期颈总动脉直径（P=0.04）的相关性更大，与年龄和心血管危险因素无关。PVWMH与DWMH与VP相关性的差异在任何年龄阈值下均无差异。我们首次发现，PVWMH与DWMH的相关性更大，与年龄无关，与动脉僵硬度和心血管重塑的血管测量结果相关，这表明体循环的变化对PVWMH和DWMH的影响不同。
The periventricular white matter is more sensitive to the systemic hemodynamic alterations than the deep white matter because of differences in its vascular structure and systemic circulation relationship. We hypothesize that periventricular white matter hyperintensity (PVWMH) volume shows greater association than deep white matter hyperintensity (DWMH) volume with vascular properties (VPs) reflecting arterial stiffness and cardiovascular remodeling, indicators of the systemic circulation. A total of 426 participants (age, 59.0±6.1 years; 57.5% women; and 39.7% Black race) in the Genetic Study of Atherosclerosis Risk who were aged ≥50 years and had brain magnetic resonance imaging were studied. VPs included pulse pressure, hypertensive response to exercise, diastolic brachial artery diameter, diastolic common carotid artery diameter, common carotid artery distensibility coefficient, and left ventricular function. The relative associations of VPs with PVWMH and DWMH as multiple measures within the same individual were determined using multilevel linear models. We also determined if age modified the differences in VPs associations with PVWMH and DWMH. Our findings indicated that, within the same subject, PVWMH volume had greater association than DWMH volume with pulse pressure (P=0.002), hypertensive response to exercise (P=0.04), diastolic brachial artery diameter (P=0.012), and diastolic common carotid artery diameter (P=0.04), independent of age and cardiovascular risk factors. The differences of PVWMH versus DWMH associations with VPs did not differ at any age threshold. We show, for the first time, that PVWMH has greater association than DWMH, independent of age, with vascular measurements of arterial stiffness and cardiovascular remodeling suggesting that changes in the systemic circulation affect the PVWMH and DWMH differently.