EFFECT OF OPIOID PEPTIDE ANTISERA ON NITROUS-OXIDE ANTINOCICEPTION IN RATS
EFFECT OF OPIOID PEPTIDE ANTISERA ON NITROUS-OXIDE ANTINOCICEPTION IN RATS
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DOI：
10.1016/0091-3057(94)90335-2
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发表时间：
1994-07-01
影响因子：
3.6
通讯作者：
SHIBUYA, T
中科院分区：
文献类型：
--
作者：
HARA, S;GAGNON, MJ;SHIBUYA, T
本研究采用热板法观察了大鼠侧脑室注射β-内啡肽（β-EP）和甲硫氨酸脑啡肽（ME）抗血清对一氧化氮（N2 O）诱导的抗伤害作用的影响。注射β-EP抗血清可逆转一氧化二氮的抗伤害效应，且剂量相关性最高可达200 μ g/大鼠。然而，400 μ g β-EP抗血清产生的一氧化二氮拮抗作用与200 μ g β-EP抗血清产生的一氧化二氮拮抗作用相当。另一方面，相似量的ME抗血清对一氧化二氮的抗伤害作用几乎没有影响。这些结果表明，β-EP可能在一氧化二氮的抗伤害效应中发挥重要作用。
This study was performed to examine the effects of ICV injection of antiserum against beta-endorphin (beta-EP) or methionine-enkephalin (ME) on nitrous oxide-induced antinociception in rats using the hot plate test. The injection of beta-EP antiserum reversed the antinociceptive effect of nitrous oxide in a dose-related manner up to 200 mu g/rat. However, antagonism of nitrous oxide by 400 mu g beta-EP antiserum was comparable to that produced by 200 mu g. On the other hand, similar amounts of ME antiserum had little effect against nitrous oxide antinociception. These findings suggest that beta-EP may play an important role in the antinociceptive effect of nitrous oxide.