Medication use modifies the health effects of particulate sulfate air pollution in children with asthma
Medication use modifies the health effects of particulate sulfate air pollution in children with asthma
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DOI：
10.2307/3433341
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发表时间：
1997-04-01
影响因子：
10.4
通讯作者：
Wichmann, HE
中科院分区：
文献类型：
--
作者：
Peters, A;Dockery, DW;Wichmann, HE
先前的对照研究表明，哮喘药物可以改变二氧化硫（SO2）对肺功能和哮喘症状的不良影响。本报告分析了药物使用在轻度哮喘儿童小组研究中的作用。来自Sokolov的儿童（n = 82）在日记中记录每日呼气峰流量（PEF）测量值、症状和药物使用情况。线性和逻辑回归分析估计直径小于2.5 μ m的硫酸盐颗粒浓度的影响，调整线性趋势，平均温度，周末（与工作日），和样本中的发热患病率。51名儿童没有服用哮喘药物，只有31名儿童目前正在服用药物。大多数儿童使用茶碱治疗，只有9名使用含有β-激动剂的喷雾剂。对于未用药的儿童，观察到5天平均硫酸盐和呼吸道症状之间的弱相关性。相比之下，服药儿童β-受体激动剂的使用增加与5天平均硫酸盐的增加直接相关，但药物使用并不能阻止PEF的降低和归因于颗粒空气污染的咳嗽患病率的增加。药物使用不是混杂因素，但削弱了颗粒空气污染与健康结果之间的关联。
Previous controlled studies have indicated that asthma medication modifies the adverse effects of sulfur dioxide (SO2) on lung function and asthma symptoms. Th present report analyzed the role of medication use in a panel study of children with mild asthma. Children from Sokolov (n = 82) recorded daily peak expiratory flow (PEF) measurements, symptoms, and medication use in a diary. Linear and logistic regression analyses estimated the impact of concentrations of sulfate particles with diameters less than 2.5 mu m, adjusting for linear trend, mean temperature, weekend (versus weekday), and prevalence of fever in the sample. Fifty-one children took no asthma medication, and only 31 were current medication users. Most children were treated with theophylline; only nine used sprays containing beta-agonist. For the nonmedicated children, weak associations between a 5-day mean of sulfates and respiratory symptoms were observed. Medicated children, in contrast, increased their beta-agonist use in direct association with an increase in 5-day mean of sulfates, but medication use did not prevent decreases in PEF and increases in the prevalence of cough attributable to particulate air pollution. Medication use was not a confounder but attenuated the associations between particulate air pollution and health outcomes.