Gene regulatory networks for development
Gene regulatory networks for development
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DOI：
10.1073/pnas.0408031102
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发表时间：
2005-04-05
影响因子：
11.1
通讯作者：
Davidson, EH
中科院分区：
文献类型：
--
作者：
Levine, M;Davidson, EH
发育的基因组程序主要通过调控编码转录因子和细胞信号传导途径组分的基因的表达来运作。该程序由顺式调节DNA（例如，增强子和沉默子）控制基因表达。发育控制基因的调控输入和功能输出构成了网络状结构。在这篇PNAS特辑中，汇集了关于线虫、苍蝇、海胆、青蛙和哺乳动物中各种组织和器官形成的发育基因调控网络的论文。在这里，我们调查这些网络的突出点，作为参考，海胆胚胎和果蝇胚胎的背腹图案的内中胚层的规范。
The genomic program for development operates primarily by the regulated expression of genes encoding transcription factors and components of cell signaling pathways. This program is executed by cis-regulatory DNAs (e.g., enhancers and silencers) that control gene expression. The regulatory inputs and functional outputs of developmental control genes constitute network-like architectures. In this PNAS Special Feature are assembled papers on developmental gene regulatory networks governing the formation of various tissues and organs in nematodes, flies, sea urchins, frogs, and mammals. Here, we survey salient points of these networks, by using as reference those governing specification of the endomesoderm in sea urchin embryos and dorsal-ventral patterning in the Drosophila embryo.