The contribution of the rat prelimbic-infralimbic areas to different forms of task switching
The contribution of the rat prelimbic-infralimbic areas to different forms of task switching
复制标题
DOI：
10.1037/0735-7044.117.5.1054
复制
发表时间：
2003-10-01
影响因子：
1.9
通讯作者：
Kiang, C
中科院分区：
文献类型：
--
作者：
Ragozzino, ME;Kim, J;Kiang, C
实验检查了大鼠前边缘-下边缘失活对不同辨别任务的获得和逆转学习的影响：实验1和2中的2-或4-选择气味辨别，实验3中从2-选择气味辨别到2-选择位置辨别的转变，以及实验4中从2-选择位置到2-选择气味辨别的转变。输注2%布比卡因不会损害气味辨别测试中的表现。边缘前-下边缘失活不会损害习得，但会损害从气味辨别到地点辨别的转变，反之亦然。对错误的分析表明，赤字是由于坚持先前的团队策略造成的。在气味位置测试中观察到的选择性缺陷表明，当条件需要抑制一种类型的属性信息的使用并学习一种新型的属性信息时，前边缘-下边缘区域可以实现行为灵活性。
The experiments examined the effects of prelimbic-infralimbic inactivation in rats on the acquisition and reversal learning of different discrimination tasks: 2- or 4-choice odor discrimination in Experiments 1 and 2, the shift from 2-choice odor discrimination to 2-choice place discrimination in Experiment 3, and the shift from 2-choice place to 2-choice odor discrimination in Experiment 4. Infusions of 2% bupivacaine did not impair performance in the odor discrimination tests. Prelimbic-infralimbic inactivation did not impair acquisition but did impair the shift from an odor to a place discrimination and vice versa. Analysis of the errors revealed that the deficit was due to perseveration of the previously teamed strategy. The selective deficits observed in the odor-place tests suggest that the prelimbic-infralimbic areas enable behavioral flexibility when conditions demand inhibiting the use of one type of attribute information and learning a new type of attribute information.