Refining the Role of Preoperative C-Reactive Protein by Neutrophil/Lymphocyte Ratio in Oral Cavity Squamous Cell Carcinoma
Refining the Role of Preoperative C-Reactive Protein by Neutrophil/Lymphocyte Ratio in Oral Cavity Squamous Cell Carcinoma
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DOI：
10.1002/lary.24105
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发表时间：
2013-11-01
期刊：
影响因子：
2.6
通讯作者：
Huang, Shiang-Fu
中科院分区：
文献类型：
--
作者：
Fang, Hsuan-Yeh;Huang, Xin Yong;Huang, Shiang-Fu
目的/假设C-反应蛋白(CRP)和新近发现的中性粒细胞/淋巴细胞比率(NLR)等炎症生物标志物升高与人类癌症的预后有关。本研究旨在分析口腔鳞状细胞癌(OSCC)患者术前血清CRP和NLR水平与临床病理因素及预后的关系。结果CRP5.0 mg/L与NLR2.44显著相关(直线回归，P
Objectives/HypothesisElevated inflammatory biomarkers such as C-reactive protein (CRP) and the recently identified neutrophil/lymphocyte ratio (NLR) were demonstrated to be associated with prognosis in human cancers. The aim of our present study is to analyze the relationship of preoperative levels of CRP and NLR with clinicopathological factors and prognosis in oral squamous cell carcinoma (OSCC) patients.Study DesignRetrospective study.MethodsThis study was performed on 226 OSCC patients between July 2007 and April 2012. Their serum CRP levels and NLR were measured preoperatively.ResultsCRP level5.0 mg/L was significantly associated with NLR2.44 (linear regression, P