Sarcopenia Is Associated with High Pulse Pressure in Older Women.
Sarcopenia Is Associated with High Pulse Pressure in Older Women.
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DOI：
10.1155/2015/109824
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发表时间：
2015
影响因子：
4.7
通讯作者：
Asano RY
中科院分区：
文献类型：
--
作者：
Coelho Júnior HJ;Aguiar Sda S;Gonçalves Ide O;Sampaio RA;Uchida MC;Moraes MR;Asano RY
介绍。肌肉减少症是一种老年综合征，与老年女性的肌肉功能、新陈代谢和认知受损有关。最近的研究表明肌肉质量的变化与心血管系统之间存在关系。然而，这种关系尚未完全阐明。方法。招募了 130 名居住在社区的巴西老年妇女（65.4 ± 6.3 岁）参与这项研究。测量了身体成分（通过生物电阻抗测量）、心血管参数（使用自动无创监测仪）和肌肉功能（使用 3 米步态速度测试）的数据。结果。与非肌少症受试者 (n = 87) 相比，肌少症老年女性 (n = 43) 的脉压 (PP) (60.3 ± 2.6mmHg) 较高，肌肉功能较低 (0.5 ± 0.0m/s) (53.7 ± 1.5mmHg; 0.9 ± 0.0m/s) (P < 0.05)。线性回归分析表明骨骼肌指数（SMI）和 PP 水平之间存在显着负相关（β = -226，P < 0.05）。此外，与非肌肉减少症女性相比，患有肌肉减少症的老年女性出现较高 PP 水平的风险增加了 3.1 倍 (IC = 1.323–7.506) (P < 0.05)。结论。与非肌肉减少症受试者相比，肌肉减少症老年女性由于 PP 水平升高而表现出较低的肌肉功能和较高的心血管风险。
Introduction. Sarcopenia is a geriatric syndrome associated with impairment of muscle function, metabolism, and cognition in older women. Recent studies have shown a relationship between changes in muscle mass and the cardiovascular system. However, this relationship has not been fully elucidated. Methods. One hundred and thirty community-dwelling Brazilian older women (65.4 ± 6.3 years) were recruited to participate in this study. Data on body composition (via bioelectrical impedance measurements), cardiovascular parameters (using an automatic and noninvasive monitor), and muscle function (using a 3-meter gait speed test) were measured. Results. Sarcopenic older women (n = 43) presented higher levels of pulse pressure (PP) (60.3 ± 2.6 mmHg) and lower muscle function (0.5 ± 0.0 m/s) compared with nonsarcopenic subjects (n = 87) (53.7 ± 1.5 mmHg; 0.9 ± 0.0 m/s) (P < 0.05). Linear regression analysis demonstrated a significantly negative association between skeletal muscle index (SMI) and PP levels (β = −226, P < 0.05). Furthermore, sarcopenic older women showed a 3.1-fold increased risk of having higher PP levels compared with nonsarcopenic women (IC = 1.323–7.506) (P < 0.05). Conclusion. Sarcopenic older women showed lower muscle function and higher cardiovascular risk due to increased PP levels compared with nonsarcopenic subjects.