Specification of Cerebellar and Precerebellar Neurons
Specification of Cerebellar and Precerebellar Neurons
复制标题
DOI：
10.1007/978-94-007-1333-8_5
复制
发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
M. Hoshino;Yusuke Seto;M. Yamada
中科院分区：
文献类型：
--
作者：
M. Hoshino;Yusuke Seto;M. Yamada
小脑被认为参与运动的调节，由小脑皮层和核中的各种类型的神经元组成。每种类型的神经元在形态学、免疫组织化学和电生理学上都有不同的特征。此外，小脑前神经传入系统还包括苔藓纤维（MF）系统和攀爬纤维（CF）系统。MF神经元分布在脑干的各种核中，并将其轴突发送到小脑颗粒细胞，而CF神经元仅位于下橄榄核（ION）并投射到浦肯野细胞。近年来发展起来的遗传谱系追踪方法和基因转移技术加速了对小脑和小脑前系统神经元亚型分子机制的研究。
The cerebellum is thought to participate in the regulation of movement and is comprised of various types of neurons in the cerebellar cortex and nuclei. Each type of neurons has morphologically, immunohistochemically, and electrophysiologically distinct characteristics. In addition, there are two precerebellar afferent systems, the mossy fiber (MF) system and the climbing fiber (CF) system. MF neurons are located in various nuclei throughout the brainstem and send their axons to cerebellar granule cells, whereas CF neurons reside exclusively in the inferior olivary nucleus (ION) and project to Purkinje cells. Recently developed genetic lineage-tracing methods as well as gene-transfer technologies have accelerated the studies on the molecular machinery to specify neuronal subtypes in the cerebellum and the precerebellar systems.