Genomic circuits and the integrative biology of cardiac diseases
Genomic circuits and the integrative biology of cardiac diseases
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DOI：
10.1038/35025196
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发表时间：
2000-09-14
期刊：
影响因子：
64.8
通讯作者：
Chien, KR
中科院分区：
文献类型：
--
作者：
Chien, KR
人类心脏病是遗传易感性和环境压力之间复杂相互作用的结果。面临的挑战是确定疾病的调节因素，并设计新的治疗策略来中断潜在的疾病途径。许多物种的基因组数据库的可用性正在揭示给定生理途径内保守的心脏特异性基因的网络。基于控制心脏形态发生、心肌细胞存活、生物力学应激反应、心肌收缩力和电传导的整合基因组回路的破坏，可以设想人类心脏病的新分类。
Human cardiac disease is the result of complex interactions between genetic susceptibility and environmental stress. The challenge is to identify modifiers of disease, and to design new therapeutic strategies to interrupt the underlying disease pathways. The availability of genomic databases for many species is uncovering networks of conserved cardiac-specific genes within given physiological pathways. A new classification of human cardiac diseases can be envisaged based on the disruption of integrated genomic circuits that control heart morphogenesis, myocyte survival, biomechanical stress responses, cardiac contractility and electrical conduction.