Blood pressure and heart rate response to repeated smoking before and after beta-blockade and selective alpha 1 inhibition.
Blood pressure and heart rate response to repeated smoking before and after beta-blockade and selective alpha 1 inhibition.
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β-阻断和选择性 α1 抑制前后重复吸烟的血压和心率反应。
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
G. Mancia
中科院分区：
文献类型：
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作者：
A. Groppelli;Stefano Omboni;G. Parati;G. Mancia
在血压正常的志愿者中，他们习惯性地每天吸烟超过20支，进行了1小时的逐搏血压记录。测量使用非侵入性的手指装置时，受试者不吸烟（1小时，控制），并在一个小时内，其中受试者被要求吸烟四支香烟，每15分钟一支。第一支香烟吸烟产生了显着增加收缩压和舒张压和心率。当吸其余三支香烟时，第一支香烟观察到的血压和心率峰值没有变化，表明重复吸烟既不会减弱也不会增加反应。然而，在每支烟之后，吸烟前的值没有恢复到基线，而是在第二、第三和第四支烟之后相继更大，这表明血压和心率在吸烟期间持续增加。与一小时的非吸烟期相比，吸烟期的收缩压、舒张压和心率的平均值分别高出18.8%、14.0%和29.7%。吸烟也增加了血压和心率的平均标准差，从而增加了变异性。在两项安慰剂对照、单盲、随机分配、交叉研究中，研究了阿替洛尔和多沙唑嗪对吸烟引起的血压和心率反应的影响。与安慰剂相比，阿替洛尔（50-100 mg，每天一次，连续4天）显著减弱了吸烟引起的心率增加，但对收缩压或舒张压的增加没有影响。（250字处删节）
In normotensive volunteers who habitually smoked more than 20 cigarettes a day, 1-h beat-to-beat blood pressure recordings were taken. Measurements were made using a non-invasive finger device when the subjects were not smoking (1 h, control) and during an hour in which the subjects were asked to smoke four cigarettes, one every 15 min. The first cigarette smoked produced a marked increase in systolic and diastolic blood pressures and the heart rate. The peak blood pressure and heart rate values observed for the first cigarette did not change when the remaining three cigarettes were smoked, indicating that the responses were neither attenuated nor increased by repeated smoking. However, after each cigarette, the pre-smoking values did not return to baseline, but were successively greater for the second, third and fourth cigarettes, indicating that blood pressure and the heart rate undergo a persistent increase during smoking. Compared with the hour-long non-smoking period, mean values over the smoking period were 18.8%, 14.0% and 29.7% higher for systolic and diastolic blood pressure and the heart rate, respectively. Cigarette smoking also increased the blood pressure and heart rate standard deviations around the mean, thereby increasing the variability. The effects of atenolol and doxazosin on the blood pressure and heart rate responses to smoking were investigated in two placebo-controlled, single-blind, randomly allocated, crossover studies. Compared with placebo, atenolol (50-100 mg given once a day for 4 days) significantly attenuated the smoking-induced increase in the heart rate but not the increase in systolic or diastolic blood pressure.(ABSTRACT TRUNCATED AT 250 WORDS)