A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration
A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration
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DOI：
10.1038/s41467-019-11262-1
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发表时间：
2019-07-26
影响因子：
16.6
通讯作者：
Farrer, Lindsay A.
中科院分区：
文献类型：
--
作者：
Handa, James T.;Rickman, Cathy Bowes;Farrer, Lindsay A.
视网膜相关性黄斑变性（AMD）是发达国家老年人中最常见的致盲原因。虽然治疗对新生血管或“湿性”形式的AMD有效，但没有治疗对非新生血管或“干性”形式成功。在这里，我们讨论了目前对干性AMD病理生物学的认识，并提出了未来的研究方向，将加快新的治疗方法的发展。在我们看来，这些应该强调系统生物学方法，将组学，药理学和临床数据整合到数学模型中，可以预测疾病的发生和进展，识别生物标志物，建立致病机制，并监测对治疗的反应。
Age-related macular degeneration (AMD) is the most common cause of blindness among the elderly in the developed world. While treatment is effective for the neovascular or "wet" form of AMD, no therapy is successful for the non-neovascular or "dry" form. Here we discuss the current knowledge on dry AMD pathobiology and propose future research directions that would expedite the development of new treatments. In our view, these should emphasize system biology approaches that integrate omic, pharmacological, and clinical data into mathematical models that can predict disease onset and progression, identify biomarkers, establish disease causing mechanisms, and monitor response to therapy.