The Complexity of Simplicity: Role of Sex, Development and Environment in the Modulation of the Stress Response.
The Complexity of Simplicity: Role of Sex, Development and Environment in the Modulation of the Stress Response.
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简单中的复杂性：性别、发展和环境在应激反应调节中的作用。
DOI：
10.1111/jne.12388
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发表时间：
2016
影响因子：
3.2
通讯作者：
Karatsoreos,IN
中科院分区：
文献类型：
--
作者：
Karatsoreos,IN
有趣的是，我们都知道压力是“复杂的”，尽管大多数压力研究都是使用令人难以置信的简化模型进行的，这可能无法让我们完全理解“真实的世界”中存在的潜在互动机制。这种简化的尝试虽然有时是必要的，但可以解释在将基础科学发现与压力和压力相关疾病的临床和流行病学数据相结合时所面临的一些困难。在2015年英国爱丁堡国际心理神经内分泌学会会议上举行的研讨会上，一系列演讲者探讨了“压力系统中可塑性的许多途径”，特别关注在许多情况下从压力研究中消除的变量，以提供更多的实验控制。具体来说，四位演讲者解决了“性，发展和环境”在压力研究中的复杂贡献，并报告了在他们自己的实验室进行的工作中发表和未发表的证据，表明在我们的实验中追求简单的比赛中，我们讲述的故事变得更加复杂。
Anecdotally, we all know that stress is ‘complicated’, although most stress research is undertaken using incredibly simplified models that may not allow us to fully understand the underlying interactive mechanisms present in the ‘real world’. This attempt at simplification, although sometimes necessary, may explain some of the difficulties faced when integrating basic science findings with the clinical and epidemiological data on stress and stress‐related disorders. In a symposium held at the 2015 International Society for Psychoneuroendocrinology meeting in Edinburgh, UK, a series of speakers explored ‘The Many Pathways to Plasticity in the Stress System’, specifically focusing on variables that, in many cases, are eliminated from studies of stress to provide increased experimental control. Specifically, four speakers tackled the complex contributions of ‘Sex, Development and Environment’ in stress research, and reported published and unpublished evidence from work conducted in their own laboratories demonstrating that, in our race for simplicity in experimentation, the stories that we tell become all the more complex.