Maintaining integrity
Maintaining integrity
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DOI：
10.1038/ncb1004-923
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发表时间：
2004-10-01
影响因子：
21.3
通讯作者：
Lehmann, AR
中科院分区：
文献类型：
--
作者：
Shiloh, Y;Lehmann, AR
对基因组稳定性和完整性的研究现在远远超出了DNA修复的生物化学，涵盖了跨越细胞生命的许多方面的信号转导途径。脱轨的基因组完整性途径可能导致衰弱的遗传疾病、过早衰老、易患癌症和退行性疾病。这一迅速扩大的领域目前的进展是2004年6月在爱尔兰戈尔韦举行的EMBO讲习班--维持基因组完整性--的主题。
Research on genome stability and integrity now extends far beyond the biochemistry of DNA repair to encompass signal transduction pathways that span numerous aspects of cellular life. Derailed genomic integrity pathways can result in debilitating genetic disorders, premature ageing, predisposition to cancer and degenerative conditions. Current progress in this rapidly expanding field was the subject of an EMBO workshop, Maintenance of Genomic Integrity, that took place in June 2004 in Galway, Ireland.