Mechanisms controlling cell cycle exit upon terminal differentiation
Mechanisms controlling cell cycle exit upon terminal differentiation
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DOI：
10.1016/j.ceb.2007.10.004
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发表时间：
2007-12-01
影响因子：
7.5
通讯作者：
Edgar, Bruce A.
中科院分区：
文献类型：
--
作者：
Buttitta, Laura A.;Edgar, Bruce A.
协调终末分化与细胞周期的永久退出对于正确的器官发生至关重要，但细胞周期在分化组织中如何被阻断仍不清楚。视网膜母细胞瘤家族蛋白和细胞周期蛋白依赖性激酶抑制剂的重要作用已被阐明，但在许多情况下，仍不清楚是什么触发了细胞周期退出。这篇评论的重点是描述。破译终末分化和细胞周期退出如何协调的最新进展。
Coordinating terminal differentiation with permanent exit from the cell cycle is crucial for proper organogenesis, yet how the cell cycle is blocked in differentiated tissues remains unclear. Important roles for retinoblastoma family proteins and Cyclin-dependent kinase inhibitors have been delineated, but in many cases it remains unclear what triggers cell cycle exit. This review focuses on describing. recent advances in deciphering how terminal differentiation and exit from the cell cycle are coordinated.