3D MR flow analysis in realistic rapid-prototyping model systems of the thoracic aorta:: Comparison with in vivo data and computational fluid dynamics in identical vessel geometries
3D MR flow analysis in realistic rapid-prototyping model systems of the thoracic aorta:: Comparison with in vivo data and computational fluid dynamics in identical vessel geometries
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DOI：
10.1002/mrm.21331
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发表时间：
2008-03-01
影响因子：
3.3
通讯作者：
Markl, M.
中科院分区：
文献类型：
--
作者：
Canstein, C.;Cachot, P.;Markl, M.
人体局部血管解剖和功能的知识对于心血管疾病的诊断和治疗具有很高的意义。基于流敏 4D MRI 与最先进的快速原型技术和计算流体动力学 (CFD) 的集成，对胸主动脉的血流动力学进行了全面分析。快速原型设计用于将对比增强磁共振血管造影测量的主动脉几何形状转化为具有大解剖覆盖范围的真实血管模型。集成到具有患者特定脉动流动条件的流动回路中，并应用流动敏感的 4D MRI，可以对真实血管几何形状中的局部和整体 3D 流动动力学进行详细分析。对特征 3D 流动模式进行可视化，对体外实验与体内数据进行定量比较，并在相同的血管几何形状中进行 CFD 模拟，以评估血管模型系统的准确性。结果表明，此类患者特异性模型系统具有对真实血管血流动力学进行详细实验模拟的潜力。需要进一步的研究来检查人体循环系统的精细边界条件的影响，例如流体-壁相互作用及其对与血管几何形状相关的正常和病理血流特征的影响。
The knowledge of local vascular anatomy and function in the human body is of high interest for the diagnosis and treatment of cardiovascular disease. A comprehensive analysis of the hemodynamics in the thoracic aorta is presented based on the integration of flow-sensitive 4D MRI with state-of-the-art rapid prototyping technology and computational fluid dynamics (CFD). Rapid prototyping was used to transform aortic geometries as measured by contrast-enhanced MR anglography into realistic vascular models with large anatomical coverage. Integration into a flow circuit with patient-specific pulsatile in-flow conditions and application of flow-sensitive 4D MRI permitted detailed analysis of local and global 3D flow dynamics in a realistic vascular geometry. Visualization of characteristic 3D flow patterns and quantitative comparisons of the in vitro experiments with in vivo data and CFD simulations in identical vascular geometries were performed to evaluate the accuracy of vascular model systems. The results indicate the potential of such patient-specific model systems for detailed experimental simulation of realistic vascular hemodynamics. Further studies are warranted to examine the influence of refined boundary conditions of the human circulatory system such as fluid-wall interaction and their effect on normal and pathological blood flow characteristics associated with vascular geometry.