Unrestricted access to methamphetamine or cocaine in the past is associated with increased current use.
Unrestricted access to methamphetamine or cocaine in the past is associated with increased current use.
复制标题
过去不受限制地获取甲基苯丙胺或可卡因与当前使用量的增加有关。
DOI：
10.1017/s1461145708009668
复制
发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Newton,TF
中科院分区：
文献类型：
--
作者：
Culbertson,C;DeLaGarza2nd,R;Costello,M;Newton,TF
与在时间有限的条件下自我给药的动物相比，允许长期自我给药兴奋剂的实验室动物的药物摄入量增加。据我们所知，这种现象尚未在人类中进行系统研究。我们采访了106（77名男性，29名女性）甲基苯丙胺（Meth）和96（81名男性，15名女性）可卡因（Coc）用户，以确定他们是否在过去经历过不受限制地获得无限量的Meth或Coc的离散时期。58名甲基苯丙胺使用者和53名古柯叶使用者报告说，过去有一段不受限制的使用时间，但现在没有。与没有无限制访问历史的Meth用户相比，具有无限制访问历史的Meth使用参与者报告了更多的Meth使用。具体而言，这些参与者报告在过去30天内使用更多的天数，每周使用更多的天数，每天使用更多的天数和每周使用更多的总天数（p<0.05）。与没有无限制访问历史的Coc用户相比，先前有无限制访问历史的Coc使用者也报告了更多的当前Coc使用。在这些参与者当前使用的所有指标中，这都是真实的，包括过去30天使用的天数更多，每周使用的天数更多，每天使用的次数更多，每周使用的总次数更高（每项p<0.02）。总之，这些结果表明，无限制地获得兴奋剂的历史与兴奋剂使用的长期增加有关。
Laboratory animals allowed to self-administer stimulants for extended periods of time escalate drug intake compared to animals that self-administer under temporally limited conditions. To our knowledge, this phenomenon has not been systematically investigated in humans. We interviewed 106 (77 male, 29 female) methamphetamine (Meth) and 96 (81 male, 15 female) cocaine (Coc) users to determine if they had experienced discrete period(s) of unrestricted access to unlimited quantities of Meth or Coc in the past. Fifty-eight Meth users and 53 Coc users reported having a discrete period of unrestricted access in the past, but not in the present. Meth-using participants with a prior history of unrestricted access reported significantly more current Meth use, compared to Meth users with no prior history of unrestricted access. Specifically, these participants reported more days used in the past 30 d, more days of use per week, greater use per day and greater total use per week (p<0.05 for each). Coc-using participants with a prior history of unrestricted access also reported significantly more current Coc use, compared to Coc users with no prior history of unrestricted access. This was true across all measures of current use for these participants, including more days used in the past 30 d, more days of use per week, greater use per day, and higher total use per week (p<0.02 for each). Taken together, these results suggest that a history of unrestricted access to stimulants is associated with long-lasting increases in stimulant use.