Determination of benzimidazole anthelmintics in meat samples.
Determination of benzimidazole anthelmintics in meat samples.
复制标题
肉类样品中苯并咪唑驱虫药的测定。
DOI：
10.1016/s0021-9673(01)84243-6
复制
发表时间：
1990
影响因子：
4.1
通讯作者：
H. Koch
中科院分区：
文献类型：
--
作者：
A. M. Martí;A. Mooser;H. Koch
建立了用高效液相色谱法测定肉类样品中8种苯并咪唑类驱虫剂的方法。方法的检出限为20~50μg/kg，回收率为66~87%。色谱柱为十八烷基硅烷柱，流动相为乙腈-水和离子对试剂，紫外检测。为了验证阳性结果，药物物质被衍生化成适合于以电子碰撞或正或负化学电离模式进行气相色谱-质谱分析的甲基或五氟苯基衍生物。
A procedure for the detection of eight benzimidazole anthelmintics in meat samples using high-performance liquid chromatography is described. The limits of detection are in the range 20–50 μg/kg with a recovery of 66-87%. Chromatography is performed on an octadecylsilane column using mobile phases of acetonitrile-water with an ion-pair reagent, with UV detection. For verification of positive results, the drug substances are derivatized to methyl or pentafluorobenzyl derivatives suitable for detection by gas chromatography-mass spectrometry in the electron-impact or positive or negative chemical-ionization mode.