Letter to the Editor: A Patient-Centered Survey-Based Assessment of Prenatal Management of Hypothyroidism for Women of Reproductive Age.
Letter to the Editor: A Patient-Centered Survey-Based Assessment of Prenatal Management of Hypothyroidism for Women of Reproductive Age.
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致编辑的信：以患者为中心、基于调查的育龄妇女甲状腺功能减退症产前管理评估。
DOI：
10.1089/thy.2022.0032
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Lee,SunY
中科院分区：
文献类型：
--
作者：
Solomon,AlexandraL;Farwell,AlanP;Pearce,ElizabethN;Lee,SunY
明显的母体甲状腺功能减退症对妊娠和儿童发育结局的不良影响有充分的文献记载（1-3）。大多数服用左旋甲状腺素（LT 4）的甲状腺功能减退孕妇需要增加25-30%的LT 4剂量以维持甲状腺功能正常（4）。因此，临床医生需要建议育龄妇女在怀孕期间进行适当的甲状腺激素替代治疗（THRT）和甲状腺功能监测。以前的研究评估了孕妇的药物依从性（5），他们对甲状腺功能减退症诊断的情绪反应（6）和医生的观点（7，8）。我们的横断面调查为基础的评估是第一次检查患者报告率和孕前THRT咨询的来源。由波士顿大学医学院机构审查委员会批准的匿名调查问卷以电子方式发送给美国甲状腺协会（ATA）通讯订阅者之友和ATA成员，以便在2020年3月12日至2020年5月18日期间分发给患者，并有一个月的提醒。纳入18-50岁诊断为甲状腺功能减退症的女性。收集人口统计学和妊娠状态、治疗临床医生类型和甲状腺激素处方、THRT咨询以及妊娠期间甲状腺功能减退症管理（如适用）相关信息。使用SAS 9.3版（SAS Institute，Inc.，卡里，北卡罗来纳州，美国）。双尾p值< 0.05被认为具有统计学显著性。
Adverse effects of overt maternal hypothyroidism on pregnancy and child developmental outcomes are well documented (1–3). Most hypothyroid pregnant women taking levothyroxine (LT4) require a 25–30% LT4 dose increase to maintain euthyroidism (4). Therefore, clinicians need to counsel reproductive-age women regarding the need for adequate thyroid hormone replacement therapy (THRT) and thyroid function monitoring during pregnancy. Previous studies assessed pregnant women’s medication adherence (5), their emotive response to hypothyroidism diagnosis (6), and physician perspective (7, 8). Our cross-sectional surveybased assessment is the first to examine patient-reported rates and sources of preconception THRT counseling. An anonymous survey questionnaire, approved by the Boston University Medical Campus Institutional Review Board, was electronically sent to Friends of the American Thyroid Association (ATA) newsletter subscribers and to ATA members for patient distribution between March 12, 2020 and May 18, 2020, with a one-month reminder. Women aged 18–50 years with diagnosed hypothyroidism were included. Demographics and information regarding pregnancy status, types of treating clinician and thyroid hormone prescribed, THRT counseling, and, if applicable, hypothyroidism management during pregnancy were collected. Chisquare tests were used to assess univariate associations, using SAS version 9.3 (SAS Institute, Inc., Cary, NC, USA). A two-tailed p-value< 0.05 was considered statistically significant.
影响因子：
40.5
作者：
Lee, Sun Y.;Pearce, Elizabeth N.
通讯作者：
Pearce, Elizabeth N.