New Research Is Shining Light on How Collateral Arteries Form in the Heart: a Future Therapeutic Direction?
New Research Is Shining Light on How Collateral Arteries Form in the Heart: a Future Therapeutic Direction?
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DOI：
10.1007/s11886-021-01460-z
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发表时间：
2021-03
影响因子：
3.7
通讯作者：
K. Red-Horse;Soumyashree Das
中科院分区：
文献类型：
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作者：
K. Red-Horse;Soumyashree Das
综述目的联合侧支动脉形成动脉-动脉吻合，在心脏中可作为天然的旁路，可减轻缺血性心脏病的各种并发症。最近使用动物模型的工作已经开始揭示冠状动脉侧支动脉形成的细节。最近的发现小鼠遗传学已被用于研究侧支动脉发育的细胞和分子机制。侧支动脉在小鼠心脏中并不是预先存在的，只是在损伤后才形成。心肌梗死造成组织缺氧，从而触发指导侧支形成的生长因子和趋化因子的表达。与成人相比，新生儿心脏侧支发育更强劲，有助于新生儿心脏再生。综述冠脉侧支发育的信号通路和细胞反应的识别为潜在的翻译策略提供了建议。对这一主题的继续研究可能导致识别诱导侧支动脉进行心脏血运重建的靶向通路。
Purpose of ReviewCollateral arteries create artery-artery anastomoses that could serve as natural bypasses that in the heart could relieve the various complications of ischemia heart disease. Recent work using animal models have begun to reveal details of how coronary collateral arteries form.Recent FindingsMouse genetics has been used to study the cellular and molecular mechanisms of collateral artery development. Collateral arteries are not pre-existing in the mouse heart, and only form in response to injury. Myocardial infarction creates tissue hypoxia that triggers the expression of growth factors and chemokines that guide collaterogenesis. Collateral development is more robust in neonatal hearts when compared with adults, and contributes to neonatal heart regeneration.SummaryThe identification of signaling pathways and cellular responses underlying coronary collateral artery development suggests potential translational strategies. Continued investigation into this subject could lead to the identification of targetable pathways that induce collateral arteries for cardiac revascularization.