Geriatric assessment to predict survival in older allogeneic hematopoietic cell transplantation recipients
Geriatric assessment to predict survival in older allogeneic hematopoietic cell transplantation recipients
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DOI：
10.3324/haematol.2014.103655
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发表时间：
2014-08-01
期刊：
影响因子：
10.1
通讯作者：
Artz, Andrew S.
中科院分区：
文献类型：
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作者：
Muffly, Lori S.;Kocherginsky, Masha;Artz, Andrew S.
异基因造血细胞移植在老年人中应用日益增多。本研究前瞻性地评估了50岁及以上受者在异基因移植前老年评估各领域的预后效用。老年评估在移植前进行，包括对功能和残疾、共病、衰弱、心理健康、营养状况和全身炎症等领域的有效测量。共有203名患者完成了老年评估并接受了移植。中位年龄为58岁（范围50 - 73岁）。在对既定的预后因素进行调整后，日常生活工具性活动受限（风险比2.38，95%置信区间：1.59 - 3.56；P
Allogeneic hematopoietic cell transplantation is increasingly utilized in older adults. This study prospectively evaluated the prognostic utility of geriatric assessment domains prior to allogeneic transplantation in recipients aged 50 years and over. Geriatric assessment was performed prior to transplant, and included validated measures across domains of function and disability, comorbidity, frailty, mental health, nutritional status, and systemic inflammation. A total of 203 patients completed geriatric assessment and underwent transplant. Median age was 58 years (range 50-73). After adjusting for established prognostic factors, limitations in instrumental activities of daily living (HR 2.38, 95% CI: 1.59-3.56; P