The CBL-CIPK Network for Decoding Calcium Signals in Plants
The CBL-CIPK Network for Decoding Calcium Signals in Plants
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DOI：
10.1007/978-3-642-20829-4_12
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发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Luan, Sheng
中科院分区：
文献类型：
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作者：
Batistic, Oliver;Kim, Kyung-Nam;Luan, Sheng
与所有其他真核生物一样，植物利用钙作为信号转导的重要第二信使。在植物中，钙信号对于触发对环境扰动或胁迫的生理反应特别重要。钙调神经磷酸酶 B 样蛋白 (CBL) 是参与环境反应的植物钙传感器蛋白的突出例子。 CBL 以钙依赖性方式调节 SNFI 相关激酶家族（称为 CBL 相互作用蛋白激酶 (CIPK)）的活性。 CBL-CIPK 网络似乎存在于所有陆地植物和某些绿藻中，尽管其功能仅在高等植物中进行了研究。在高等植物中，该网络通常由大约 10 个 CBL 和 25-30 个 CIPK 组成。通过这些蛋白质之间的组合相互作用，CBL-CIPK 网络能够整合植物环境的多个信号，并协调下游对营养缺乏或有毒离子暴露等胁迫的反应。因此，CBL-CIPK 网络代表了响应细胞外信号的各种钙信号的主要解码机制。
Like all other eukaryotes, plants utilize calcium as an important secondary messenger for signal transduction. Among plants, calcium signals are particularly important for triggering physiological responses to environmental perturbations or stresses. Calcineurin B-Like proteins (CBLs) are prominent examples of plant calcium-sensor proteins involved in environmental responses. CBLs regulate the activities of a family of SNFI-related kinases, known as CBL-interacting protein kinases (CIPKs), in a calcium-dependent manner. The CBL-CIPK network appears to be present in all land plants and certain green algae, though its functions have only been studied in higher plants. Among higher plants, the network typically consists of about 10 CBLs and 25-30 CIPKs. Through combinatorial interactions among these proteins, the CBL-CIPK network enables integration of multiple signals of the plant's environment and coordinates downstream responses to stresses such as nutrient deprivation or toxic ion exposure. The CBL-CIPK network thus represents a major decoding mechanism for various calcium signatures in response to extracellular cues.