Increased Proportion of HLA-Class-I-Specific Natural Killer Cell Receptors (CD94) on Peripheral Blood Mononuclear Cells after Allogeneic Bone Marrow Transplantation
Increased Proportion of HLA-Class-I-Specific Natural Killer Cell Receptors (CD94) on Peripheral Blood Mononuclear Cells after Allogeneic Bone Marrow Transplantation
复制标题
同种异体骨髓移植后外周血单核细胞中 HLA-I 类特异性自然杀伤细胞受体 (CD94) 的比例增加
作者：
J. Tanaka;Y. Tutumi;Li Zhang;A. Mori;K. Kahata;N. Toyoshima;Shuichi Ohta;Sumiko Kobayashi;S. Hashino;M. Asaka;M. Imamura
在本研究中，我们研究了CD94/NKG2A对同种异体骨髓移植（BMT）后PBMC的抑制自然杀伤细胞受体（NKR）表达。CD94在无慢性移植物抗宿主病（cGVHD）患者以及对常规免疫抑制治疗反应良好的cGVHD患者PBMC上的表达比例高于应答不良的cGVHD患者。CD94+/CD3+细胞和CD94+/CD8+细胞的比例在cGVHD患者中较高，反应良好。此外，非cGVHD患者中表达nkg2a的细胞比例高于cGVHD患者。因此，同种异体骨髓移植后的慢性同种异体刺激可能会增加CD94/ nkg2a阳性细胞的比例，这些细胞可能在某些患者的同种异体反应中起一定的调节作用。
In the present study, we investigated the inhibitory natural killer cell receptor (NKR) expression of CD94/NKG2A on PBMC after allogeneic bone marrow transplantation (BMT). The proportion of CD94 expression on PBMC was higher in patients without chronic graft-versus-host disease (cGVHD) and also in cGVHD patients with good response to conventional immunosuppressive therapy than in cGVHD patients with poor response. Also, the proportions of CD94+/CD3+ cells and CD94+/CD8+ cells were higher in cGVHD patients showing good response. In addition, the proportion of NKG2A-expressing cells was higher in patients without cGVHD than in patients with cGVHD. Therefore, chronic allostimulation after allo-BMT may augment the proportion of CD94/NKG2A-positive cells, and these cells may play some role in the regulation of alloresponse in some patients.