A single night of partial sleep loss impairs fasting insulin sensitivity but does not affect cephalic phase insulin release in young men
A single night of partial sleep loss impairs fasting insulin sensitivity but does not affect cephalic phase insulin release in young men
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DOI：
10.1111/jsr.12340
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发表时间：
2016-02-01
影响因子：
4.4
通讯作者：
Benedict, Christian
中科院分区：
文献类型：
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作者：
Cedernaes, Jonathan;Lampola, Lauri;Benedict, Christian
本研究旨在调查一晚的部分睡眠剥夺（PSD）是否会改变人类的空腹胰岛素敏感性和头相胰岛素释放（CPIR）。响应与食物相关的感官刺激而增加的循环胰岛素可能会准备好组织来分解摄入的葡萄糖，例如，葡萄糖。通过刺激限速糖酵解酶。此外，考虑到胰岛素一旦到达大脑就具有抑制食欲的特性，CPIR 可以作为早期外周饱腹感信号。在此背景下，在本研究中，16 名男性参加了两个单独的疗程：一晚 PSD（睡眠 4.25 小时）与一晚完全睡眠（睡眠 8.5 小时）。在每种睡眠条件后的早晨，受试者的口腔用1摩尔蔗糖溶液冲洗45秒，之前和之后进行血液采样以重复测定血浆葡萄糖和血清胰岛素浓度（-3、+3、+5、+7、+10和+20分钟）。我们的主要结果是，与充分睡眠相比，PSD 与显着较高的外周胰岛素抵抗相关，正如胰岛素抵抗指数较高的空腹稳态模型评估所表明的那样（+16%，P=0.025）。相比之下，在两种睡眠条件下均未观察到 CPIR。我们的研究结果表明，一晚的 PSD 就足以损害健康男性的空腹胰岛素敏感性。相比之下，用蔗糖溶液短暂冲洗口腔并不会改变血清胰岛素浓度，这表明 CPIR 减弱不太可能是急性睡眠不足导致人类早晨代谢紊乱的机制。
The present study sought to investigate whether a single night of partial sleep deprivation (PSD) would alter fasting insulin sensitivity and cephalic phase insulin release (CPIR) in humans. A rise in circulating insulin in response to food-related sensory stimulation may prepare tissues to break down ingested glucose, e.g. by stimulating rate-limiting glycolytic enzymes. In addition, given insulin's anorexigenic properties once it reaches the brain, the CPIR may serve as an early peripheral satiety signal. Against this background, in the present study 16 men participated in two separate sessions: one night of PSD (4.25h sleep) versus onenight of full sleep (8.5h sleep). In the morning following each sleep condition, subjects' oral cavities were rinsed with a 1-molar sucrose solution for 45s, preceded and followed by blood sampling for repeated determination of plasma glucose and serum insulin concentrations (-3, +3, +5, +7, +10 and +20min). Our main result was that PSD, compared with full sleep, was associated with significantly higher peripheral insulin resistance, as indicated by a higher fasting homeostasis model assessment of insulin resistance index (+16%, P=0.025). In contrast, no CPIR was observed in any of the two sleep conditions. Our findings indicate that a single night of PSD is already sufficient to impair fasting insulin sensitivity in healthy men. In contrast, brief oral cavity rinsing with sucrose solution did not change serum insulin concentrations, suggesting that a blunted CPIR is an unlikely mechanism through which acute sleep loss causes metabolic perturbations during morning hours in humans.