Preoperative evidence of circulating tumor cells by means of reverse transcriptase-polymerase chain reaction for carcinoembryonic antigen messenger RNA is an independent predictor of survival in non-small cell lung cancer: A prospective study
Preoperative evidence of circulating tumor cells by means of reverse transcriptase-polymerase chain reaction for carcinoembryonic antigen messenger RNA is an independent predictor of survival in non-small cell lung cancer: A prospective study
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DOI：
10.1067/mtc.2002.124370
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发表时间：
2002-08-01
影响因子：
6
通讯作者：
Ogawa, M
中科院分区：
文献类型：
--
作者：
Yamashita, J;Matsuo, A;Ogawa, M
目的：我们对连续 103 例接受根治性肺叶切除术的非小细胞肺癌患者进行前瞻性研究，探讨通过癌胚抗原信使 RNA 逆转录酶聚合酶链反应在外周血中检测到的循环肿瘤细胞是否是非小细胞肺癌患者的独立于肿瘤分期的预后指标。我们对1996年3月至1998年4月期间接受根治性肺叶切除术的非小细胞肺癌患者在术前诊断时和术后2至3周再次进行分析。我们以单变量和多变量的方式分析了非小细胞肺癌患者中癌胚抗原信使RNA表达的预后价值。结果：术前血样中癌胚抗原信使RNA的患者与那些没有癌胚抗原信使RNA的人相比，其生存率较差。在这些患者中，术后血样中含有癌胚抗原信使 RNA 的患者生存率最差。多因素逐步分析选取术前癌胚抗原信使RNA表达（P=.0004；相对风险，0.21）和疾病病理分期（P=.0002；相对风险，1.43）作为生存的独立预后因素。结论：术前外周血中癌胚抗原信使RNA的分子检测是非小细胞患者的独立预后因素。接受根治性手术的肺癌。 J Thorac Cardiovasc Surg 2002；124：299-305
Objective:We conducted a prospective study of 103 consecutive patients with non-small cell lung cancer who underwent a curative lobectomy to test whether circulating tumor cells detected in the peripheral blood by means of reverse transcriptase-polymerase chain reaction of carcinoembryonic antigen messenger RNA is a prognostic indicator independent of tumor stage in patients with non-small cell lung cancer.Methods:We assayed for carcinoembryonic antigen messenger RNA by means of reverse transcriptase-polymerase chain reaction in peripheral blood taken at the time of diagnosis before an operation and again 2 to 3 weeks after an operation from patients with non-small cell lung cancer who underwent a curative lobectomy between March 1996 and April 1998. We analyzed the prognostic value of carcinoembryonic antigen messenger RNA expression in the patients with non-small cell lung cancer in a univariate and multivariate manner.Results:Patients with carcinoembryonic antigen messenger RNA in the preoperative blood samples had a poor survival when compared with those without carcinoembryonic antigen messenger RNA. Of these patients, the worst survival was seen in those with carcinoembryonic antigen messenger RNA in the postoperative blood samples. The multivariate stepwise analysis selected the preoperative carcinoembryonic antigen messenger RNA expression (P=.0004; relative risk, 0.21) and the pathologic stage of disease (P=.0002; relative risk, 1.43) as the independent prognostic factors for survival.Conclusions:The molecular detection of carcinoembryonic antigen messenger RNA in the preoperative peripheral blood is an independent prognostic factor in patients with non-small cell lung cancer who undergo a curative operation.J Thorac Cardiovasc Surg 2002;124:299-305