MicroRNAs as promising biomarkers for gastric cancer
MicroRNAs as promising biomarkers for gastric cancer
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DOI：
10.3233/cbm-2012-00284
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发表时间：
2012-01-01
影响因子：
3.1
通讯作者：
Ren, Wen-Jun
中科院分区：
文献类型：
--
作者：
Wang, Fang;Sun, Guo-Ping;Ren, Wen-Jun
尽管治疗取得了有希望的进展，但胃癌（GC）的总体结果仍然很差。目前的肿瘤标志物由于敏感性和特异性相对较低，并不理想。在GC的临床管理中迫切需要确定更特异、更敏感的新型标志物。 MicroRNA (miRNA) 是非编码 RNA 分子。近年来，miRNA研究已迅速从癌症的基础分子研究转向临床应用领域。基于最新数据，本综述主要总结了 miRNA 作为分子生物标志物在 GC 疾病易感性、诊断、预后和药物反应预测中的潜在作用。本综述还强调了 GC 中的 miRNA 表达谱及其与癌症分类和亚型分层的关系。尽管肿瘤相关miRNA的研究领域还存在诸多挑战，但小分子未来必将改善GC的临床管理。
Despite promising developments of treatment, the overall outcome of gastric cancer (GC) remains poor. Current tumor markers are not ideal due to relatively low sensitivity and specificity. There is an urgent need for identifying more specific and more sensitive novel markers in the clinical management of GC. MicroRNAs (miRNAs) are non-coding RNA molecules. Recently, miRNA studies have quickly moved from basic molecular research of cancer to areas of clinical application. On the basis of recent data, the present review mainly summarizes the potential role of miRNAs as molecular biomarkers for disease susceptibility, diagnosis, prognosis and drug-response prediction in GC. This review also highlights the miRNA expression profiles in GC and their relation to cancer classification and subtype stratification. Although there are still many challenges in the research field of tumor-related miRNAs, the small molecules will definitely improve the clinical management of GC in the future.