Adenosine A2A receptor interactions with receptors for other neurotransmitters and neuromodulators
Adenosine A2A receptor interactions with receptors for other neurotransmitters and neuromodulators
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DOI：
10.1016/s0014-2999(99)00230-7
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发表时间：
1999-06-30
影响因子：
5
通讯作者：
Ribeiro, JA
中科院分区：
文献类型：
--
作者：
Ribeiro, JA
腺苷通过激活腺苷A（2A）受体，在调节影响神经递质释放和/或突触传递的多种受体的激活方面似乎具有至关重要的功能，特别是神经肽受体（降钙素基因相关肽（CGRP）和血管活性肠肽（VIP）），以及NMDA受体、代谢性谷氨酸受体、烟碱性自促进受体、多巴胺受体和腺苷A(1)受体。这些A（2A）受体参与与其他神经递质和/或神经调节剂受体相互作用的方式，为这种“无所不在”的核苷的作用开辟了新的途径。无论是通过直接的受体-受体调节，还是通过受体后机制，腺苷在保护细胞免受损伤的“困扰”中，使用尽可能多的受体系统来同步突触传递，以发挥这种核苷保护神经系统的“命运”。(C) 1999 Elsevier Science B.V.版权所有
Adenosine, by activating adenosine A(2A) receptors, seems to have a crucial function in regulating the activation of multiple receptors that affect neurotransmitter release and/or synaptic transmission, in particular receptors for neuropeptides (calcitonin gene related peptide (CGRP) and vasoactive intestinal peptide (VIP)), and NMDA receptors, metabotropic glutamate receptors, nicotinic autofacilitatory receptors, dopamine receptors and adenosine A(1) receptors. The manner in which these A(2A) receptors are involved in interactions with the receptors for other neurotransmitters and or neuromodulators opens novel avenues for the action of this 'omnipresent' nucleoside. Either by direct receptor-receptor modulation or by post-receptor mechanisms, adenosine, in its 'obsession' to protect cells from insults, uses as many receptor systems as possible to synchronize synaptic transmission, in order to exert what seems to be the 'destiny' of this nucleoside -protection of the nervous system. (C) 1999 Elsevier Science B.V. All rights reserved.